
	International Journal of Pharmacology
	Year: 2015 \| Volume: 11 \| Issue: 1 \| Page No.: 43-49 DOI: 10.3923/ijp.2015.43.49

Effect of Aqueous Extract of Fenugreek (Trigonella foenum-graecum L.) On Selected Biochemical and Oxidative Stress Biomarkers in Rats Intoxicated with Carbon Tetrachloride

S.I. Al-Sultan and S.M. El-Bahr

Abstract: The objective of the current study was to investigate the protective effects of aqueous extract of fenugreek (Trigonella foenum-graecum L.) against carbon tetrachloride (CCl₄), induced hepatotoxicity in rats. Therefore, twenty rats were fed standard diet and divided into four groups. Rats in the first and second groups were injected i/p with paraffin oil and received either tap water (control 1) or aqueous extract of fenugreek (control 2), respectively. Rats in the third and fourth groups were injected i/p with CCl₄ and received either tap water or aqueous extract of fenugreek, respectively. At the end of the experiment (5 weeks), blood and liver samples were collected. Sera were used for selected biochIical analysis and liver tissues were used for estimation of selected oxidative stress biomarkers. The present findings revealed that, CCl₄ elevated serum transaminases, hepatic lipid peroxidation and hepatic enzymatic antioxidants activities. Oral fenugreek aqueous extract ameliorated the detrimental effects of CCl₄ and corrected all examined biomarkers toward the control values. The present study concluded that aqueous extract of fenugreek plays a protective role against CCl₄-induced liver damages in rats. These protective effects were in the form of improvIent of serum transaminases, attenuation of hepatic lipid peroxidation and activation of hepatic antioxidant enzymes.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Effect of Flaxseed on Lipid Profile, Antioxidants and PPAR-α Gene Expression in Rabbit Fed Hypercholesterolemic Diet

•	Hepatic Gene Expression, Antioxidant Enzymes and Anti-diabetic Effect of Nigella sativa in Diabetic Rats

•	Effect of Aflatoxin B₁ on Histopathology and Oxidative Stress Biomarkers in Testis of Rats with Special References to Gene Expression of Antioxidant Enzymes

•	Effect of Aqueous Extract of Green Tea (Camellia sinensis) on Hematology and Oxidative Stress Biomarkers in Rats Intoxicated with Carbon Tetrachloride

•	Camel Milk Regulates Gene Expression and Activities of Hepatic Antioxidant Enzymes in Rats Intoxicated with Carbon Tetrachloride

•	Hepatoprotective Effects of Camel Milk against CCl₄-induced Hepatotoxicity in Rats

How to cite this article:

S.I. Al-Sultan and S.M. El-Bahr, 2015. Effect of Aqueous Extract of Fenugreek (Trigonella foenum-graecum L.) On Selected Biochemical and Oxidative Stress Biomarkers in Rats Intoxicated with Carbon Tetrachloride. International Journal of Pharmacology, 11: 43-49.

DOI: 10.3923/ijp.2015.43.49

URL: https://scialert.net/abstract/?doi=ijp.2015.43.49

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		Thomson ISI

Science Alert