Subscribe Now Subscribe Today
Science Alert
Curve Top
International Journal of Pharmacology
  Year: 2014 | Volume: 10 | Issue: 4 | Page No.: 225-230
DOI: 10.3923/ijp.2014.225.230
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Blood Pressure Lowering Effect of Morus alba is Mediated Through Ca++ Antagonist Pathway

Munasib Khan, Arif-ullah Khan, Najeeb-ur-Rehman and Anwarul-Hassan Gilani

Morus alba has been used in traditional medicine system for the treatment of hypertension. Our objective was to provide scientific basis for the medicinal use of M. alba in hypertension. The crude extract of Morus alba (Ma.Cr) induced a dose-dependent (10-100 mg kg-1) fall in the arterial BP in anaesthetized rats. In isolated guinea-pig atria, Ma.Cr caused inhibition of atrial force and rate of spontaneous contractions, similar to that exhibited by verapamil. When tested in rat aortic ring preparations, Ma.Cr at concentration range of 0.1-10 mg mL-1 relaxed high K+ (80 mM) and phenylephrine (PE, 1 μM)-induced contractions and shifted the Ca++ dose-response curves to right, like caused by verapamil. These data indicate that the blood pressure lowering action of Morus alba occurred via., Ca++ channel blockade pathway, which provides evidence for the pharmacological basis to justify its effectiveness in hypertension.
PDF Fulltext XML References Citation Report Citation
  •    Studies on Blood Pressure Lowering, Vasodilator and Cardiac Suppressant Activities of Vitex negundo: Involvement of K+ Channel Activation and Ca++ Channel Blockade
  •    Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents
  •    The Spasmogenic and Spasmolytic Activities of Lavandula stoechas are Mediated Through Muscarinic Receptor Stimulation and Calcium Channel Blockade
  •    Synthesis and Pharmacological Screening of 1-(2`, b s4`-dimethoxyphenacyl)-4-hydroxy-4-phenylpiperidinium bromide
  •    The Vasorelaxant Effects of Anaxagorea luzonensis A. Grey in the Rat Aorta
How to cite this article:

Munasib Khan, Arif-ullah Khan, Najeeb-ur-Rehman and Anwarul-Hassan Gilani, 2014. Blood Pressure Lowering Effect of Morus alba is Mediated Through Ca++ Antagonist Pathway. International Journal of Pharmacology, 10: 225-230.

DOI: 10.3923/ijp.2014.225.230






Curve Bottom