Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents

Research Article

**Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents**

A. Boye, G.A. Koffuor, P. Amoateng, E.O. Ameyaw and A.K. Abaitey

This study presented the analgesic and safety assessment of Heliotropium indicum, a plant traditionally used for the management of abdominal pains, dysmenorrhoea and post-labour inflammatory conditions in Ghana using formalin-induced pain model in mice. For comparison of analgesic effect, morphine (1-10 mg kg^-1) and diclofenac sodium (1-10 mg kg^-1) were used as a reference opioid and NSAID, respectively. The aqueous and ethanolic extracts (30-300 mg kg^-1) dose-dependently inhibited both the first and second phases of the formalin-induced nociception. Oral doses of the aqueous extract (1-5 g kg^-1) in imprint control region mice were well tolerated in acute toxicity studies; however a 14-day oral administration of 1-2 g kg^-1 of the extracts in sprague-Dawley rats produced pathologic effects on the heart, kidney, liver and lungs. Therefore, although the aqueous and ethanolic extracts of H. indicum have analgesic activity, it could have a cumulative toxic effects hence prolonged and continuous use is not advised.

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A. Boye, G.A. Koffuor, P. Amoateng, E.O. Ameyaw and A.K. Abaitey, 2012. Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents. International Journal of Pharmacology, 8: 91-100.

DOI: 10.3923/ijp.2012.91.100

URL: https://scialert.net/abstract/?doi=ijp.2012.91.100

International Journal of Pharmacology

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Authors

A. Boye

G.A. Koffuor

P. Amoateng

E.O. Ameyaw

A.K. Abaitey

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Research Article

**Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents**

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