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International Journal of Pharmacology

Year: 2012 | Volume: 8 | Issue: 6 | Page No.: 535-541
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Authors

Shanmugapriya Perumal

Roziahanim Mahmud

Suthagar Pillai Piaru

Lee Wei Cai

Surash Ramanathan

Keywords

The present study was aimed at evaluating the antioxidant and cytotoxic activities of methanolic extracts from two ethnomedicinal plants growing wild in Malaysia and often used as both herbal medicine and food: Ziziphus mauritiana and Syzygium polyanthum. The plant extracts were tested for total phenolic and flavonoid contents as well as for in vitro antioxidant activities by DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging assay, reducing power and β-carotene/linoleic acid bleaching assay. The stem bark extract of Z. mauritiana showed a potent free radical scavenging activity as evidenced by low EC50 at 20.09±0.19 μg mL-1. Interestingly, Z. mauritiana leaf extract demonstrated higher reducing power activity (EC50: 20.62±0.34 μg mL-1) than ascorbic acid (EC50: 20.69±0.49 μg mL-1). The oxidation of linoleic acid was effectively inhibited by S. polyanthum leaf extract with 91.43±2.52%. In addition, both plant extracts exhibited no cytotoxic effect against Vero cell line. The results revealed that the methanolic extracts of Z. mauritiana and S. polyanthum possess promising antiradical properties and therefore can be used as a safe, reliable and economical natural source in pharmaceutical application and food industry.
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