Subscribe Now Subscribe Today
Science Alert
Curve Top
International Journal of Pharmacology
  Year: 2012 | Volume: 8 | Issue: 6 | Page No.: 496-509
DOI: 10.3923/ijp.2012.496.509
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

The Mechanisms of Positive Effects of Melatonin in Dyslipidemia: A Systematic Review of Animal and Human Studies

Shilan Mozaffari, Shirin Hasani-Ranjbar and Mohammad Abdollahi

Dyslipidemia and following atherosclerosis as a chronic affection remain one major cause of death all over the world. Given multiple reports on positive effects of melatonin on dyslipidemia, there is a need for reviewing all these studies in order to reach a convincing conclusion. Towards this goal, we have reviewed all previous investigations on use of melatonin in dyslipidemia found from PubMed, Cochrane, Google Scholar, Scopus and web of Science up to January 2012. Of the publications identified in the initial database, 11 clinical trials and 43 nonclinical trials (18 in vitro and 25 animal studies) were included and reviewed. Most of the results reveal the potency of melatonin as an antioxidant in preventing lipid peroxidation through different mechanisms and therefore, improving the lipid profile. Melatonin has anti-inflammatory and antioxidative effects, neutralizes free radicals, increases antioxidative enzymes and glutathione levels, prevents electron leakage from the mitochondrial respiratory chain, acts synergistically with vitamin C, E and glutathione, reduces levels of pro-inflammatory cytokines and therefore prevents Low-density Lipoprotein (LDL) oxidation and decreases lipid peroxidation. The results indicate a need for further studies on safety/efficacy measures if melatonin was used in long-term.
PDF Fulltext XML References Citation Report Citation
  •    Recent Update on Animal and Human Evidences of Promising Anti-diabetic Medicinal Plants: A Mini-review of Targeting New Drugs
  •    A Systematic Review of the Efficacy and Safety of Anti-aging Herbs in Animals and Human
  •    Effects of the Mixture of Melissa officinalis L., Cinnamomum zeylanicum and Urtica dioica on Hepatic Enzymes Activity in Patients with Nonalcoholic Fatty Liver Disease
  •    Benefit of Lemon Verbena in Healthy Subjects; Targeting Diseases Associated with Oxidative Stress
How to cite this article:

Shilan Mozaffari, Shirin Hasani-Ranjbar and Mohammad Abdollahi, 2012. The Mechanisms of Positive Effects of Melatonin in Dyslipidemia: A Systematic Review of Animal and Human Studies. International Journal of Pharmacology, 8: 496-509.

DOI: 10.3923/ijp.2012.496.509






Curve Bottom