Subscribe Now Subscribe Today
Science Alert
Curve Top
International Journal of Pharmacology
  Year: 2012 | Volume: 8 | Issue: 4 | Page No.: 252-258
DOI: 10.3923/ijp.2012.252.258
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Cardioprotective Effect of a Medicinal Mushroom, Ganoderma lucidum Against Adriamycin Induced Toxicity

M. Rajasekaran and C. Kalaimagal

The present study was conducted to evaluate the cardioprotective role of a medicinal mushroom, Ganoderma lucidum against the toxicity of an anticancer drug adriamycin. Wistar rats were administered with adriamycin (1.5 mg kg-1 b.wt.) for three weeks to induce cardiotoxicity. Another group was treated with adriamycin and Ganoderma extract (250 mg kg-1) for 30 days. Adriamycin treatment resulted in increased serum levels of marker enzymes such as alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK). Besides increasing the lipid peroxidation (LPO), adriamycin significantly reduced antioxidant enzymes, glutathione peroxidase (GPx), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) in the heart tissue. Level of reduced glutathione (GSH) was also significantly reduced. However, in G. lucidum extract treated rats the alterations were not significant, but found to be nearer to the control. The study shows that G. lucidum extract exhibits significant antioxidant property and protect the heart from free radical mediated toxicity of adriamycin.
PDF Fulltext XML References Citation Report Citation
  •    Protective Effect of N-acetyl Cysteine and/or Pro Vitamin A against Monosodium Glutamate-Induced Cardiopathy in Rats
  •    Interaction of Propranolol with Garlic in Isoproterenol Induced Myocardial Infarction in Rat
  •    Phytotherapy in Cardiovascular Diseases: From Ethnomedicine to Evidence Based Medicine
  •    Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats
How to cite this article:

M. Rajasekaran and C. Kalaimagal, 2012. Cardioprotective Effect of a Medicinal Mushroom, Ganoderma lucidum Against Adriamycin Induced Toxicity. International Journal of Pharmacology, 8: 252-258.

DOI: 10.3923/ijp.2012.252.258






Curve Bottom