
	International Journal of Pharmacology
	Year: 2011 \| Volume: 7 \| Issue: 8 \| Page No.: 874-879 DOI: 10.3923/ijp.2011.874.879

Antibacterial Activities of Curcumin Bioconjugates

Archana Pandey, Ravindra Kumar Gupta, Anudita Bhargava and Babita Agrawal

Abstract: Curcumin is a wonder molecule as it is used for prevention and cure of multiple diseases such as cancer, diabetes, inflammation, cataract, rheumatoid arthritis, HIV etc., However, it has not been possible so far to assign a definite drug profile because of low bioavailability, fast metabolism, poor adsorption, low solubility and lack of targeted delivery. Several bioconjugate of curcumin with amino acids and nucleotides have been prepared so far to overcome these limitations. In the present study the two new conjugates of curcumin have been synthesized by esterifying its phenolic group functions with nicotinic acid (vitamin B₃) and its isomer picolinic acid viz. 1,7-bis (4-O-nicotinoyl-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione (2) and 1, 7-bis (4-O-picolinoyl-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione (4). These bioconjugate were evaluated for antibacterial activity against medically important gram positive cocci (Entercoccus faecium) and gram negative bacilli (Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa). Antibacterial activity was performed by microdilution broth susceptibility method in vitro. Results demonstrated that both bioconjugates possess high antibiotic potential as evidenced by enhanced antibacterial activity in comparison to pure curcumin. On the basis of results it may concluded that lipophilic nature of these conjugates enhances the cellular uptake and may be better option for medicinal and pharmacological applications.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Curcumin and Tetrahydrocurcumin Restore the Impairment of Endothelium-dependent Vasorelaxation Induced by Homocysteine Thiolactone in Rat Aortic Rings

•	Amelioration of Nicotine-Induced Damage of Blood Cells in Protein Malnourished Female Rats by Curcumin

•	Schistosomicidal Effect of Curcumin

•	Antimicrobial Activity Evaluation of Cassia spectabilis Leaf Extracts

•	The Potency of Endophytic Fungi of Turmeric (Curcuma longa L.) in Biotransformation of Curcumin Compounds in Various Media

How to cite this article:

Archana Pandey, Ravindra Kumar Gupta, Anudita Bhargava and Babita Agrawal, 2011. Antibacterial Activities of Curcumin Bioconjugates. International Journal of Pharmacology, 7: 874-879.

DOI: 10.3923/ijp.2011.874.879

URL: https://scialert.net/abstract/?doi=ijp.2011.874.879

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		Thomson ISI

Science Alert