
	International Journal of Pharmacology
	Year: 2011 \| Volume: 7 \| Issue: 5 \| Page No.: 664-669 DOI: 10.3923/ijp.2011.664.669

Virgin Coconut Oil Prevents Nicotine Dependence and Relapse

Kusnandar Anggadiredja, Anggraini Barlian, Yangie Dwi Marga Pinang and Dian Anggraeny

Abstract: Nicotine is an addictive substance with detrimental effects on health. Several measures have been developed to help addicts quit smoking, yet the rate of increase in number of smokers does not seem to have slowed down. The current study was aimed to investigate the effect of Virgin Coconut Oil (VCO) on nicotine dependence and relapse using Conditioned Place Preference (CPP) paradigm in rats. The rats were randomly assigned to one of the following treatment groups: place conditioning without drug treatment before nicotine (0.5 mg kg^-1, i.p.); place conditioning with oral VCO at 5 mL kg^-1 or the reference drug diclofenac (3.2 mg kg^-1, i.p.) 30 min prior to each nicotine treatment. The conditioning training lasted for 5 days, followed by conditioning test on the following day. In different batch of rats, the conditioning test continued with a 7-day nicotine-free period and the rats were then challenged on the following day with 0.5 mg kg^-1 nicotine intraperitoneally. VCO and diclofenac were given 30 minutes before nicotine challenge to test their effects. Results showed that VCO and diclofenac significantly decreased (p<0.01) the preference to nicotine-paired compartment to those of preconditioning levels in both preference tests. Taken together, results of the present study indicate that VCO prevents nicotine dependence as well as relapse. The results further lay foundation for the development of potent agents for nicotine dependence.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Demulsification of Virgin Coconut Oil by Centrifugation Method: A Feasibility Study

•	Pollution Impacts of Cigarette Consumption on Indoor Air Quality in Nigeria

•	Innovative Integrated Wet Process for Virgin Coconut Oil Production

•	Opinions of Turkish University Students on Cigarette Smoking at Schools

•	The Social Factors Implicated in Cigarette Smoking in a Jordanian Community

How to cite this article:

Kusnandar Anggadiredja, Anggraini Barlian, Yangie Dwi Marga Pinang and Dian Anggraeny, 2011. Virgin Coconut Oil Prevents Nicotine Dependence and Relapse. International Journal of Pharmacology, 7: 664-669.

DOI: 10.3923/ijp.2011.664.669

URL: https://scialert.net/abstract/?doi=ijp.2011.664.669

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)

Science Alert