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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 5 | Page No.: 659-663
DOI: 10.3923/ijp.2011.659.663
 
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Influence of Tinospora cordifolia Root Extract Supplementation on Hematological and Serological Parameters of Male Mice Exposed to Aflatoxin B1

Veena Sharma, Rekha Gupta, Nidhi Mishra and Shatruhan Sharma

Abstract:
This study was undertaken to evaluate the effectiveness of ethanolic extract of Tinospora cordifolia root extract in alleviating the toxicity of aflatoxin B1 (AFB1) in male swiss albino mice. Forty eight male swiss albino mice (30±5 g) were exposed to aflatoxin B1 (2 μg 30/g body weight, orally) either individually or in combination with Tinospora cordifolia (50, 100, 200 mg kg-1, orally) once daily for 25 days. Evaluation was made for haemato-serological parameters. The results suggested that aflatoxin B1 exposure led to significant fall (p<0.01) in haemoglobin, erythrocyte count and significant rise (p<0.01) in platelet count, total leukocyte count, segmented neutrophil, lymphocyte count (p<0.05), serum glutamate oxaloacetate transaminase, Serum glutamate pyruvate transaminase and alkaline phosphatase whereas no significant difference was seen in haematocrit, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin content. Treatment with plant extract alone had no negative effects on most of the parameters. Concomitant administration of all three plant doses along with aflatoxin significantly diminished the adverse effect of aflatoxin and altered most of the haematological and serological variables.
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How to cite this article:

Veena Sharma, Rekha Gupta, Nidhi Mishra and Shatruhan Sharma, 2011. Influence of Tinospora cordifolia Root Extract Supplementation on Hematological and Serological Parameters of Male Mice Exposed to Aflatoxin B1. International Journal of Pharmacology, 7: 659-663.

DOI: 10.3923/ijp.2011.659.663

URL: https://scialert.net/abstract/?doi=ijp.2011.659.663

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