Submit Manuscript

International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 6 | Page No.: 896-902
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 432

Authors

A.R. Ebadollahi Natanzi

M.H. Ghahremani

H.R. Monsef Esfehani

M.B. Minaei

H. Nazarian

O. Sabzevari

Keywords

In this study, Nasturtium officinale R. Br. (watercress), an edible plant from cruciferous plants and its three fractions were screened for their hepatoprotective effects against acetaminophen induced toxicity in rats. The total parts of plant were extracted with alcohol-water and then sequentially fractionated. The total extract and its three fractions namely; petroleum ether; n-butyl alcohol; and aqueous at two doses (50 and 175 mg kg-1) were administrated to animals every 24 h for five successive days. Rats treated as post treatment with the total extract or three fractions at the dose of 175 mg kg-1 did not show any significance change in activity of aminotransferse enzymes (AST and ALT) compared to control. Acetaminophen caused significant hepatocellular damage and increase in serum levels of AST, ALT and LDH in comparison to control group (p<0.001). Post treatment with the total extract (175 mg kg-1) and aqueous fraction (50 mg kg-1) significantly prevented acetaminophen induced rise in serum levels of AST, ALT and LDH. LD50 value of the petroleum fraction was more than 3823 mg kg-1, while the other two fractions and total extract were non-toxic up to 5734 mg kg-1. Histopathological changes of liver induced by acetaminophen were considerably reversed following treatment by aqueous fraction and total extract of N. officinale. The findings of this study showed that N. officinale may play a protective role against acetaminophen-induced hepatotoxicity through maintaining the normal liver functions which further validates the use of N. officinale in Iranian traditional medicine as a hepatoprotective agent.
PDF Fulltext XML References Citation

Related Articles

91-day Oral Toxicity Evaluation of a Herbal Preparation Used in the Management of Breast Tumour in Southwestern Nigeria using Mice
Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci
Protective Activity of Fumaria vaillantii Extract and Monomethyl Fumarate on Acetaminophen Induced Hepatotoxicity in Mice
Aqueous Extract of Iranian Green Tea Prevents Lipid Peroxidation and Chronic Ethanol Liver Toxicity in Rat
The Hepatoprotective Effect of Senna occidentalis Methanol Leaf Extract Against Acetaminophen-induced Hepatic Damage in Rats
Hepatoprotective and Antioxidant Effect of Andrographis echioides N. against Acetaminophen Induced Hepatotoxicity in Rats
Hepatoprotective Action of Zerumbone Against Paracetamol Induced Hepatotoxicity
Hepatoprotective and Antioxidant Action of Moringa oleifera Lam.Against Acetaminophen Induced Hepatotoxicity in Rats
Antioxidant Activity and Hepatoprotective Potential of Black Seed, Honey and Silymarin on Experimental Liver Injuries Induced by CCl4 in Rats
Protective Effect of a Herbal Formula Against Carbontetrachloride Induced Hepatotoxicity

Leave a Comment

Your email address will not be published. Required fields are marked *