Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 5 | Page No.: 676-680
DOI: 10.3923/ijp.2010.676.680
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Modulatory Effects of Ascorbic Acid and α-tocopherol on Arsenic Induced Micronuclei Formation

B.S. Balakumar, R. Suresh and R. Venugopal

Abstract:
Arsenic is a well known human carcinogen and has many other toxic effects. Sodium arsenite, a compound of arsenic, capable of inducing genotoxic effects through oxidative stress, is evaluated for its genotoxic effect by the formation of micronuclei in the polychromatic erythrocytes in the bone marrow cells of Wistar rats. Further, the modulatory effects of antioxidants like ascorbic acid and α-tocopherol on arsenic intoxicated rats is investigated. Therefore, the present study was designed to determine whether the oral supplementation of α-tocopherol (400 mg kg-1 body weight) and ascorbic acid (200 mg kg-1 b.wt.) to arsenic-intoxicated rats (100 ppm in drinking water) for 30 days, modulates the genotoxicity caused by arsenic through the formation of micronuclei (p<0.05). The findings suggest that co-treatment of ascorbic acid and α-tocopherol to arsenic-exposed rats protects the antioxidant system and modulates arsenic induced micronuclei formation.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Occupational Exposure as a Risk Factor to Enhance the Risk of Early Ageing
  •    Antioxidant and Anticoagulant Properties of Phyllanthus fraternus GL Webster (Family: Euphorbiaceae)
  •    Arsenic Trioxide Selectively Induces Apoptosis Within the Leukemic Cells of APL Patients with t (15;16) Translocation
How to cite this article:

B.S. Balakumar, R. Suresh and R. Venugopal, 2010. Modulatory Effects of Ascorbic Acid and α-tocopherol on Arsenic Induced Micronuclei Formation. International Journal of Pharmacology, 6: 676-680.

DOI: 10.3923/ijp.2010.676.680

URL: https://scialert.net/abstract/?doi=ijp.2010.676.680

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom