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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 5 | Page No.: 664-669
DOI: 10.3923/ijp.2010.664.669
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A Comparative Study on the Antioxidant and Glucose-lowering Effects of Curcumin and Bisdemethoxycurcumin Analog through in vitro Assays

S. Sivabalan and C.V. Anuradha

Type 2 diabetes has emerged as an epidemic affecting millions of people all over the world. Several research findings suggest that oxidative stress is the triggering factor for the development of type 2 diabetes. Hyperglycemia and oxidative stress go hand in hand to accelerate the disease progression in a vicious cycle. In India, the medicinal herb Curcuma longa is used as a culinary food additive and also as a therapeutic agent for diabetes. Recent research evidenced that the curcuminoids present in Curcuma longa have several medicinal properties including anti-diabetic property. However, the bioavailability of curcumin is very less compared to its derivatives and its synthetic analogs. The synthetic analog of bisdemethoxycurcumin is reported to have increased bioavailability and stability but its effect on controlling oxidative stress, glucose absorption and gluconeogenesis have not yet been explored. The aim of this study was to evaluate the anti-oxidant and glucose lowering effects of bisdemethoxycurcumin analog (BDMCA) in comparison with curcumin. Anti-oxidant activity of BDMCA and curcumin was evaluated by measuring the rate of inhibition of iron-ascorbate induced lipid peroxidation in liver homogenate in vitro. Effect of these drugs on intestinal glucose absorption in Wistar rats and on gluconeogenesis in liver homogenate in vitro was evaluated to know their glucose lowering effects. We found that both the BDMCA and curcumin lower the gluconeogenesis in the hepatocytes and function as antioxidants in vitro in a similar manner. Both BDMCA and curcumin delays the intestinal glucose absorption but BDMCA delays the intestinal glucose absorption more effectively compared to curcumin.
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  •    Antihypercholesterolemic Effect of Combination of Guazuma ulmifolia Lamk. Leaves and Curcuma xanthorrhiza Roxb. Rhizomes Extract in Wistar Rats
  •    Curcumin and Tetrahydrocurcumin Restore the Impairment of Endothelium-dependent Vasorelaxation Induced by Homocysteine Thiolactone in Rat Aortic Rings
  •    Antibacterial Activities of Curcumin Bioconjugates
  •    How to Cope with Dengue in Developing Countries Like Pakistan?
  •    Chemical Studies on a Curcumin Analogue Produced by Endophytic Fungal Transformation
  •    Interaction Between Curcumin and Opioid System in the Formalin Test of Rats
How to cite this article:

S. Sivabalan and C.V. Anuradha, 2010. A Comparative Study on the Antioxidant and Glucose-lowering Effects of Curcumin and Bisdemethoxycurcumin Analog through in vitro Assays. International Journal of Pharmacology, 6: 664-669.

DOI: 10.3923/ijp.2010.664.669






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