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International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 1 | Page No.: 63-67
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Authors

S.M. Raquibul Hasan

M.M. Hossain

R. Akter

M. Jamila

M.E.H. Mazumder

M.A. Alam

A. Faruque

S. Rana

S. Rahman

Keywords

Analgesic potential of the pet ether (PECB), chloroform (CCB), n-butanol (NBCB) and hydromethanolic (HMCB) fractions of the aerial parts of Commelina benghalensis Linn. was evaluated for centrally acting analgesic property using hotplate and tail immersion method and peripheral pharmacological actions using acetic acid-induced writhing test to scientifically validate some of the folkloric and ethnomedical uses of the plant. All fractions, at the dose of 200 and 400 mg kg-1 b.wt., displayed significant analgesic action in a dose dependent manner in the tested models. In acetic acid-induced writhing test, all extracts exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; the response decreased in the order Diclofenac-Na (76.16%) > CCB2 (68.8%) > NBCB2 (61.9%) > HMCB2 (52.8%) > PECB2 (48.0%). In hotplate and tail immersion method, all fractions caused a significant (p<0.0-0.001) increase in latency time and the results are comparable to the standard drug Nalbuphine. These results suggest significant analgesic potential of C. benghalensis and thereby justify its traditional uses in various types of pain.
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How to cite this article

S.M. Raquibul Hasan, M.M. Hossain, R. Akter, M. Jamila, M.E.H. Mazumder, M.A. Alam, A. Faruque, S. Rana and S. Rahman, 2010. Analgesic Activity of the Different Fractions of the Aerial Parts of Commelina benghalensis Linn. International Journal of Pharmacology, 6: 63-67.

DOI: 10.3923/ijp.2010.63.67

URL: https://scialert.net/abstract/?doi=ijp.2010.63.67

Comments

Md. Masud Reply

I am confused about the calculation of %inhibition at 90 min in Table 3. I am not finding here exact calculation.

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