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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 4 | Page No.: 480-486
DOI: 10.3923/ijp.2010.480.486
 
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Studies of Behavioural and Neural Mechanism of Aridanin Isolated from Tetrapleura tetraptera in Mice

A.O. Aderibigbe, E.O. Iwalewa, S.K. Adesina and O.I. Agboola

Abstract:
The aim of the present study was to investigate the central nervous system depressant effect and neural mechanisms of Aridanin in mice. Novelty-induced rearing, head dips, locomotor activity and effect on learning and memory were studied. Aridanin at 5, 10, 20 and 30 mg kg-1 b.wt. reduced novelty-induced rearing and locomotor activity in mice. Head dip reduction was noticed only with the highest dose (30 mg kg-1, i.p.) while in Y-maze, a reduction in number of entrance (locomotion) with no change in percentage alternation on short term working memory was obtained. Aridanin reversed the central excitatory effect of flumazenil in the methods. These results confirm the central depressant properties of Aridanin which may be mediated through GABAA receptor.
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How to cite this article:

A.O. Aderibigbe, E.O. Iwalewa, S.K. Adesina and O.I. Agboola, 2010. Studies of Behavioural and Neural Mechanism of Aridanin Isolated from Tetrapleura tetraptera in Mice. International Journal of Pharmacology, 6: 480-486.

DOI: 10.3923/ijp.2010.480.486

URL: https://scialert.net/abstract/?doi=ijp.2010.480.486

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