• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 6 (4), 2010
  3. 386-392
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 4 | Page No.: 386-392
DOI: 10.3923/ijp.2010.386.392

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 219

Authors


Mohamed Rafiq

Country: India

S.K. Mitra

Country: India

Keywords


  • acarbose
  • insulin resistance
  • Salacia reticulata
  • glucose intolerance
  • rosiglitazone
Research Article

Purified Methanolic Extract of Salacia reticulata Wight. Ameliorates Insulin Resistance and Metabolic Alterations in Rats Fed High Fructose Diet

Mohamed Rafiq and S.K. Mitra
The present study was carried-out to investigate the insulin sensitizing activity of purified methanolic extract of salacia reticulata roots in fructose-fed rats, a well-known model of insulin resistance and hyperinsulinemia. Feeding fructose enriched diet caused a hyperinsulinemic state and increased insulin resistance index with statistically significant increase in fasting triglyceride and very low density lipoprotein-cholesterol levels. Fructose fed rats also exhibited glucose intolerance when tested by oral glucose tolerance test as indicated by increase in total area under curve of blood glucose. Dietary supplementation of purified methanolic extract of Salacia reticulata (0.4 g/100 g of feed) significantly reversed the fructose diet-induced metabolic alterations in rats and also improved glucose intolerance. The effect of purified methanolic extract of Salacia reticulata was comparable to that of rosiglitazone, a known insulin sensitizer. Acarbose, a marketed α-glucosidase inhibitor failed to reverse the metabolic alterations caused by fructose enriched diet in rats. The finding proves probable mechanism of action of Salacia reticulata and further validates scientific basis of its usage in the management of various metabolic disorders including diabetes.
PDF Fulltext XML References Citation

How to cite this article

Mohamed Rafiq and S.K. Mitra, 2010. Purified Methanolic Extract of Salacia reticulata Wight. Ameliorates Insulin Resistance and Metabolic Alterations in Rats Fed High Fructose Diet. International Journal of Pharmacology, 6: 386-392.

DOI: 10.3923/ijp.2010.386.392

URL: https://scialert.net/abstract/?doi=ijp.2010.386.392

Related Articles

Influence of Terminalia bellerica Roxb. Fruit Extracts on Biochemical Parameters in Streptozotocin Diabetic Rats
Role of Diasulin, an Herbal Formulation on Antioxidant Status in Chemical Induced Diabetes
Comparative Evaluation of Hypoglycaemic Activity of Two Medicinal Plants in Alloxan Diabetic Rats

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved