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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 1 | Page No.: 25-30
DOI: 10.3923/ijp.2010.25.30
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Hyperlipidemia Enhanced Oxidative Stress and Inflammatory Response Evoked by Renal Ischemia/Reperfusion Injury

Y.S. Bhalodia, N.R. Sheth, J.D. Vaghasiya and N.P. Jivani

This study was designed to investigate possible effect of hyperlipidemia on renal ischemia/ reperfusion injury in rat. Male Wistar albino rats were divided into 4 groups. Hyperlipidemia was induced by cholesterol (500 mg kg-1 p.o.) feeding in hydrogenated ground nut oil (as a vehicle) for 4 weeks. At the end of 4th week renal ischemia/reperfusion injury was perform by occlusion of both renal vascular pedicles for 60 min, followed by 24 h reperfusion. During reperfusion period, blood and urine were collected for biochemical analysis. Both kidneys were isolated, one kidney for histopathological evaluation and one for tissue parameters. The lipid peroxidation, xanthine oxidase activity and nitric oxide level in renal tissue were significantly increased after I/R in hyperlipidemic rats compared to ischemia/reperfusion in normal rats. Antioxidant enzymes like reduced glutathione, superoxide dismutase and catalase were significantly reduced after ischemia/reperfusion in hyperlipidemic rats compared to normal rats. Serums TNF-α level and myeloperoxidase activity in renal tissue, were also significantly increased after ischemia/reperfusion in hyperlipidemic rats. Furthermore, hyperlipidemic rats that underwent ischemia/reperfusion, showed severe tubular cell swelling, interstitial edema, tubular dilatation and moderate to severe necrosis. Hyperlipidemia enhanced renal ischemia/reperfusion injury by elevation of oxidative stress and inflammatory responses.
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How to cite this article:

Y.S. Bhalodia, N.R. Sheth, J.D. Vaghasiya and N.P. Jivani, 2010. Hyperlipidemia Enhanced Oxidative Stress and Inflammatory Response Evoked by Renal Ischemia/Reperfusion Injury. International Journal of Pharmacology, 6: 25-30.

DOI: 10.3923/ijp.2010.25.30






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