Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 2 | Page No.: 138-141
DOI: 10.3923/ijp.2010.138.141
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Antihyperlipidemic Activity of Gymenma sylvestre R. Br. Leaf Extract on Rats Fed with High Cholesterol Diet

P.R. Rachh, M.R. Rachh, N.R. Ghadiya, D.C. Modi, K.P. Modi, N.M. Patel and M.T. Rupareliya

Abstract:
Effect of Gymnema sylvestre R. Br. Leaf extract on high cholesterol fed diet rats was investigated. Hyperlipidemia was induced in rats by giving high cholesterol diet (2% cholesterol, 1% sodium cholate and 2% coconut oil) for seven days in standard rat chow diet. The hydroalcoholic extract of Gymnema sylvestre R. Br. leaves (200 mg kg-1 b.wt.) was orally administered once a day to rats fed with a high cholesterol diet for seven days. High cholesterol fed diet rats exhibited significant increase in total serum cholesterol, triglycerides, low density lipoproteins, very low density lipoprotein and significant decrease in high density lipoproteins. Treatment with hydroalcoholic extract of Gymnema sylvestre R. Br. leaves significantly decreased total serum cholesterol, triglycerides, low density lipoproteins, very low density lipoprotein and increased the high density lipoproteins in hyperlipidemic rats and was comparable with that of standard atorvastatin. Hence, it was concluded that significant antihyperlipidemic activity of hydroalcholic extract of Gymnema sylvestre R. Br. leaves may be due to the presence of acidic compounds, flavonoids, phenols, saponins, tannis (Phenolic compounds) and triterpenoids found in the preliminary phytochemical screening.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Protective Effects of Saponin-Rich Aqueous Leaf Extract of Gymnema sylvestre R. Br. against Cafeteria and High-Fat Diet-Induced Obesity and Oxidative Stress in Rats
  •    A Review on the Recent Advances in Pharmacological Studies on Medicinal Plants; Animal Studies are Done but Clinical Studies Needs Completing
  •    Review on Medicinal Plants used by Local Community of Jodhpur District of Thar Desert
  •    Hypoglycaemic and Hypolipidemic Activities of Rauwolfia serpentina in Alloxan-Induced Diabetic Rats
How to cite this article:

P.R. Rachh, M.R. Rachh, N.R. Ghadiya, D.C. Modi, K.P. Modi, N.M. Patel and M.T. Rupareliya, 2010. Antihyperlipidemic Activity of Gymenma sylvestre R. Br. Leaf Extract on Rats Fed with High Cholesterol Diet. International Journal of Pharmacology, 6: 138-141.

DOI: 10.3923/ijp.2010.138.141

URL: https://scialert.net/abstract/?doi=ijp.2010.138.141

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom