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International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 2 | Page No.: 134-137
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Authors

Ali M. Bahrami

Valadi Ali

Keywords

Research Article

Effects of Anethum chryseum Leaves Extracts on Gastric Irritation

Ali M. Bahrami and Valadi Ali
As a folk remedy, Anethum chryseum leaves is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum chryseum in mice. Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g kg-1 i.p., (1.5, 6.16) and 6.98 g kg-1, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. chryseum leaves extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.
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