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International Journal of Pharmacology

Year: 2008 | Volume: 4 | Issue: 6 | Page No.: 466-471
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Authors

M. Hassanpour Fard

S.L. Bodhankar

Madhumira Dikshit

Keywords

Research Article

Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats

M. Hassanpour Fard, S.L. Bodhankar and Madhumira Dikshit
The aim of present study was to investigate the cardioprotective effect of Lagenaria siceraria (LS) fruit powder against the cardiotoxicity of doxorubicin (Dox) in rats. Male wistar rats (250-300 g) were randomly divided into three groups. Group 1-was control (gum acacia 2%), group 2-Dox (10 mg kg-1), group 3-Dox+LS (200 mg kg-1 for 18 days). Dox (10 mg kg-1 i.v.) was administered in group 2 and 3 on day 16. After anesthetizing the animals on the 18th day, electrocardiogram (ECG) was recorded and blood was investigated for creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) while determination of superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidation (LPO) and histopathology was carried out for heart. Group 3 animals showed decreased QT and ST intervals (p<0.01 and p<0.05, respectively) and non significant increase in heart rate as compared to group 2. Significant decrease in serum CK-MB, AST (p<0.001) and LDH (p<0.05) of group 3 animals was observed as compared to group 2. There was significant increase in the level of GSH (p<0.05) and non significant increase in SOD, whereas lipid peroxidation (p<0.01) was inhibited in group 3 as compared to group 2. Histopathological study of LS treated group showed protection against myocardial toxicity induced by doxorubicin. Acute toxicity study showed that LS was safe at 5000 mg kg-1. It is concluded that Lagenaria siceraria possessed cardioprotective effect against doxorubicin induced cardiotoxicity in rats.
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