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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 5 | Page No.: 361-368
DOI: 10.3923/ijp.2008.361.368
 
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Local Delivery of Metronidazole and Chlorhexidine as Toothpaste in Treatment of Adult Periodontitis

N. Jenabian, M. Abedi, P. Tayebi and A.A. Moghadamnia

Abstract:
The present study was done to assess the effect of topically-applied toothpaste containing metronidazole (MTZ) and chlorhexidine (CHX) alone or in combination as an adjunctive non-surgical therapy in patients with Adult Periodontitis (AP). Eighty adult patients (50 females and 30 males, mean age of 35 years) with chronic moderate to advanced periodontitis participated in this trial. Following baseline clinical examination, including assessments of Plaque Index (PI), PPD, Clinical Attachment Level (CAL), Gingival Index (GI) and Bleeding on Probing (BOP), careful oral hygiene was instructed. The patients were randomly assigned to one of four treatment groups; placebo (toothpaste without antibacterial agents), MTZ 1%, CHX 0.2% and combined toothpaste of MTZ 1% and CHX 0.2%. Scaling and Root Planning (SRP) was done in two sessions one week before investigation. Clinical re-examination was performed at the end of week 2-4 after application of toothpaste. At the baseline the Mean ± SD of PI for placebo (control treatment) and combined treatment group were 1.62 (0.83) and 1.62 (0.6) and after 4 weeks of treatment were 1.42 (0.7) and 0.85 (0.52), respectively (p < 0.001). The improvement in CAL of drug receiving subjects was greater than that of placebo (p = 0.002). Combined treatment group showed more improvement in PI, GI and BOP in compared with other groups. According to the results, for improving the parameters, combination of MTZ 1% and CHX 0.2% in toothpaste composition could be more effective than each of them alone.
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How to cite this article:

N. Jenabian, M. Abedi, P. Tayebi and A.A. Moghadamnia, 2008. Local Delivery of Metronidazole and Chlorhexidine as Toothpaste in Treatment of Adult Periodontitis. International Journal of Pharmacology, 4: 361-368.

DOI: 10.3923/ijp.2008.361.368

URL: https://scialert.net/abstract/?doi=ijp.2008.361.368

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