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International Journal of Pharmacology

Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 287-291
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Authors

S. Meera

V.S.S.S. Gupta Atyam

N.S. Kumar

Keywords

Research Article

Immunomodulatory and Antioxidant Activity of a Polyherbal Formulation

S. Meera, V.S.S.S. Gupta Atyam and N.S. Kumar
Immunomodulatory and antioxidant activity of Guard Sansar, a Polyherbal Formulation (PHF) was assessed by carbon clearance assay and adhesion of neutrophils to nylon fibers, in Swiss albino mice and by estimation of Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), catalase (CAT) and reduced Glutathione (GSH) from blood of pyrogallol-treated Wistar rats, respectively, using Levamisole as reference standard. The PHF showed significant immunomodulatory activity by increasing the rate of carbon clearance and the percent neutrophil adhesion to nylon fibers. The oxidative stress, evidenced as elevation of LPO and reduction of SOD, CAT and GSH, was reversed by pre treatment with Polyherbal Formulation. Guard Sansar possesses immunostimulatory and antioxidant activity.
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