Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 3 | Page No.: 202-207
DOI: 10.3923/ijp.2008.202.207
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

MMP-13 Inhibitory Activity of Thirteen Selected Plant Species from Okinawa

Changwei Ao, Anping Li, Abdelnaser A. Elzaawely and Shinkichi Tawata

Abstract:
The methanol extracts of thirteen medicinal plants from Okinawa, Japan were examined for Matrix Metalloproteinase-13 (MMP-13) inhibitory activity. Among the thirteen selected species, Curcuma longa, Ocimum basilicum and Curcuma aromatica showed high inhibitory effect with IC50 values of 27.8, 81.7 and 85.8 μg mL-1, respectively. The chemical compositions of these three plant extracts were determined by LC-MS. Curcumin was the predominant constituent of C. longa and C. aromatica (58.6 and 28.7 mg g-1 extract, respectively), whilst O. basilicum mainly contained rosmarinic acid with amount of 47.3 mg g-1 extract. Both of curcumin and rosmarinic acid exhibited excellent MMP-13 inhibitory activity (IC50: 3.6 and 2.9 μM, respectively). The results indicate that curcumin and rosmarinic acid might be potent MMP-13 natural inhibitors.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    General Practices on Indigenous Knowledge System Technology in Selected Regions of Namibia
  •    Tissue Inhibitors of Matrix Metalloproteinase-3, Potential Therapeutic Target against Multiple Sclerosis
  •    AT1 Receptors Activation Enhances the Expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 Melanoma Cells
  •    A New Therapeutic Approach to Neutralize Throat Surface Proteases and Virus Glycoproteins Simultaneously for the Treatment of Influenza Virus Infection
How to cite this article:

Changwei Ao, Anping Li, Abdelnaser A. Elzaawely and Shinkichi Tawata, 2008. MMP-13 Inhibitory Activity of Thirteen Selected Plant Species from Okinawa. International Journal of Pharmacology, 4: 202-207.

DOI: 10.3923/ijp.2008.202.207

URL: https://scialert.net/abstract/?doi=ijp.2008.202.207

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom