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International Journal of Pharmacology

Year: 2008 | Volume: 4 | Issue: 2 | Page No.: 153-156
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Authors

Sussan Soltani Mohammadi

Mirsadegh Seyedi

Keywords

Research Article

Comparing Oral Gabapentin Versus Clonidine as Premedication on Early Postoperative Pain, Nausea and Vomiting after General Anesthesia

Sussan Soltani Mohammadi and Mirsadegh Seyedi
This study was designed to compare the effects of small dose of oral gabapentin with clonidine as premedication; on early postoperative pain, nausea and vomiting (PONV) in patients undergoing elective abdominal surgeries under general anesthesia. In a randomized placebo controlled study, 120 ASA I and II patients scheduled for elective abdominal surgeries were randomly assigned to receive either 0.2 mg oral clonidine (n = 40), 300 mg gabapentin (n = 40) or placebo (n = 40) 1 h before surgery. They anesthetized with the same technique. Demographic data, post operative pain scores, nausea and vomiting and total morphine consumption by PCA pump after the operation were recorded in the recovery room and during first 6 h after the operation. VAS score more than 3 points assumed clinically important for postoperative pain management. Demographic data was not statistically different between the study groups. Two patients in gabapentin compared with 13 patients in Clonidine group (p = 0.01) and 29 patients in placebo group (p = 0.014) had VAS >3 in recovery room. The mean morphine consumption were 4.75 ± 7.5 mg in placebo, 1.95 ± 5.51 mg in Clonidine and 1.56 ± 1.5 mg in gabapentin group in recovery (Clonidine vs placebo, p = 0.032; gabapentin vs placebo, p = 0.024; gabapentin vs Clonidine, p = 0.045). These measurements were 18 ± 15.8, 13.1 ± 12.6, 12.1 ± 12.9 mg during first 6 h after operation; in placebo, Clonidine and gabapentin groups, respectively (Clonidine vs placebo, p = 0.017; gabapentin vs placebo, p = 0.023; gabapentin vs Clonidine, p = 0.067). PONV was not statistically different between the study groups in the recovery room and during first 6 h after the operation. This study showed that oral premedication with 300 mg gabapentin reduce postoperative pain and total morphine consumption but not PONV during recovery and first 6 h after abdominal surgeries.
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