Impact of Sildenafil Citrate (Viagra) and Ethanol Interaction on Antioxidant Defense System in the Adult Male Albino Rats

Research Article

Impact of Sildenafil Citrate (Viagra) and Ethanol Interaction on Antioxidant Defense System in the Adult Male Albino Rats

T.G. Sivasankaran, R. Udayakumar, K. Panjamurthy and V. Albert Singh

The interactive effects of Sildenafil citrate (VIAGRA) and Ethanol Consumption on the antioxidant defense system in testis tissue of rats were studied in the present research work. Male Albino rats were divided into eight groups of six animals each. Control rats were administered normal saline orally. While experimental animals were fed Sildenafil citrate (VIAGRA) (1 μg gm^-1) and 18% ethanol (5 g kg^-1 Body weight) and sacrificed. A significant depletion of GSH content in testis was observed. This combination was found to be decreased Super Oxide Dismutase (SOD) activity in testis. Thio Barbituric Acid Reactive Substrate (TBARS) and Catalase (CAT) Activity were observed to be increased in testis. In contrast, Glutathione Peroxidase (GPx) activity was decreased in testis. The results are discussed in detail.

PDF Fulltext XML References Citation

How to cite this article

T.G. Sivasankaran, R. Udayakumar, K. Panjamurthy and V. Albert Singh, 2007. Impact of Sildenafil Citrate (Viagra) and Ethanol Interaction on Antioxidant Defense System in the Adult Male Albino Rats. International Journal of Pharmacology, 3: 55-60.

DOI: 10.3923/ijp.2007.55.60

URL: https://scialert.net/abstract/?doi=ijp.2007.55.60

International Journal of Pharmacology

Article Trend

Total views 52

Authors

T.G. Sivasankaran

R. Udayakumar

K. Panjamurthy

V. Albert Singh

Keywords

Research Article

Impact of Sildenafil Citrate (Viagra) and Ethanol Interaction on Antioxidant Defense System in the Adult Male Albino Rats

How to cite this article

Related Articles

Leave a Reply