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International Journal of Pharmacology

Year: 2007 | Volume: 3 | Issue: 2 | Page No.: 149-154
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Authors

Sivanandham Velavan

Vava Mohaideen Hazeena Begum

Keywords

Research Article

Modulatory Role of Asparagus racemosus on Glucose Homeostasis in Aged Rats

Sivanandham Velavan and Vava Mohaideen Hazeena Begum
Normal aging is usually associated with a progressive deterioration in most endocrine functions that may be responsible for serious disturbances of metabolic homeostasis. Impairment of glucose homeostasis is a well-known feature of aging. Regulation of glucose metabolism is a key aspect of metabolic homeostasis and insulin is the dominant hormone influencing this regulatory system. Glucose seems to be central to the phenomenon of aging and age-related diseases. Medicinal plants are believed to be much safer and proved elixir in the treatment of various ailments. The modulatory effect of Asparagus racemosus on plasma glucose, insulin, insulin resistance index and metabolic liver enzymes such as hexokinase, glucose-6-phosphatase and fructose-1,6-bisphosphatase were evaluated in young and aged rats. In aged rats, the increased levels of all the variables except the activity of hexokinase were observed. Supplementation of Asparagus racemosus root extract (ARRE) to aged rats restored the age associated altered activity of enzymes and plasma parameters. The results of the present study suggest that the ARRE regulated the glucose homeostasis in aged rats as like young rats. Supplementation could maintain the activity of enzymes and plasma parameters in young rats. These modulatory effects of ARRE may be attributed to the presence of enriched therapeutic phytochemical constituents.
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