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International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 362-365
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Authors

B.A. Adeniyi

R.O. Odufowoke

S.B. Olaleye

Keywords

Research Article

Antibacterial and Gastroprotective Properties of Eucalyptus torelliana [Myrtaceae] Crude Extracts

B.A. Adeniyi, R.O. Odufowoke and S.B. Olaleye
The antibacterial and gastroprotective properties of crude extracts of Eucalyptus torelliana were investigated. Antibacterial activity was investigated by screening the crude extracts for activity against clinically isolated strains of wound bacteria viz., Staphylococcus aureus UCH 2010, Pseudomonas aeruginosa UCH 2125, Escherichia coli UCH 2007, Klebsiella species UCH 2694 and Proteus mirabilis CHO 2014. The dichloromethane crude extracts demonstrated highest antibacterial activity against all tested microorganisms at 10 mg mL-1 concentration. The gastroprotective effect of the crude extract of the leaf was investigated in albino rats. This was evaluated against gastric mucosal damage induced by ethanol/HCl mixture. Ethanol/HCl mixture (1.5 mL of 0.15 N HCl in 70% ethanol) caused severe gastric mucosal damage with ulcer index of 2.7±0.33. Pre-treatment of animals with crude extract of Eucalyptus torelliana leaf 200 and 1000 mg kg-1 orally for 1h significantly reduced the Pre-treatment of animals with 50 mg kg -1. Ranitidine for 1 h reduced the reduced the formation of ulcer by the ethanol HCl mixture with preventive ratios 56 and 92.5%, respectively. Ranitidine (50 mg kg-1) afforded 92.5% protection. The results therefore suggest that crude extracts of Eucalyptus torelliana possess both antibacterial and gastroprotective properties.
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