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International Journal of Pharmacology
  Year: 2005 | Volume: 1 | Issue: 4 | Page No.: 324-328
DOI: 10.3923/ijp.2005.324.328
 
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Protective Effects of Polygonum viviparum L. Root and its Extracts Against Lipid-peroxidation Induced by Indomethacin in Rats

Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan

Abstract:
Polygonum viviparum, root has been used in the folkloric medicine for the treatment of a many diseases including gastrointestinal disorders. Powdered roots of Polygonum viviparum (PV) and its aqueous (PV-A) and ethanol (PV-E) extracts were evaluated for anti-ulcerogenic efficacy in rats with ulcer lesions in the glandular stomach induced by indomethacin (25 mg kg-1)subcutaneously, to rationalize the folkloric uses. The pretreatment of PV protected the experimental rats against gastric changes caused by indomethacin in a dose-dependent manner. PV-A and PV-E extracts (equivalent to 2.0 g kg-1) of the powder also inhibited the indomethacin-induced effects on gastric juice volume, pH, acid-output and ulcer index. PV, PV-A and PV-E showed highly significantly in vitro acid buffering and pepsin binding activities. The data indicates that PV and its extracts protect the gastric mucosa against indomethacin-induced gastric changes, may result from their lipid peroxidation/apoptosis inhibition.
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How to cite this article:

Rifat-uz-Zaman , Muhammad Shoaib Akhtar and Muhammad Shafiq Khan , 2005. Protective Effects of Polygonum viviparum L. Root and its Extracts Against Lipid-peroxidation Induced by Indomethacin in Rats. International Journal of Pharmacology, 1: 324-328.

DOI: 10.3923/ijp.2005.324.328

URL: https://scialert.net/abstract/?doi=ijp.2005.324.328

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