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International Journal of Cancer Research
  Year: 2010 | Volume: 6 | Issue: 4 | Page No.: 188-201
DOI: 10.3923/ijcr.2010.188.201
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Perspective of DNA Methylation in Cancer Research

Mohammed A. Ibrahim

DNA methylation is one of three epigenetic mechanisms which has seen increasing interest among cancer researchers, as changes in DNA methylation have emerged as one of the most consistent molecular aberrations in various neoplasms. Aberration of DNA methylation have been identified in the global genomic DNA (hyper or hypo methylation) or within CpG islands in promoter regions of tumor suppressor genes. Several types of bacteria which cause chronic infections are associated with cancer development and chronic infection of Helicobacter pylori might give rise to changes in pattern of DNA methylation. Recent discoveries are giving evidence in the involvement of aberration in DNA methylation in conferring resistance to antitumor agents, and efforts of molecular biologists are directed to overcome this problem by introducing new epigenomic drugs which reform DNA methylation, and help in tumor therapy. Another interesting prospective of current research in DNA methylation is the possibility of development molecular markers for early detection of tumors. The objectives of this article are to review various recent progress of DNA methylation in cancer research.
PDF Fulltext XML References Citation Report Citation
  •    Platinum Resistance: The Role of Molecular, Genetic and Epigenetic Factors
  •    Molecular Diagnostics and Therapy of Acute Myeloid Leukemia
  •    An Insight into the Use of Genome, Methylome and Gethylome in Synthetic Biology
  •    Epigenetics and Esophageal Cancer: Role of Altered Methylation in Specific Genes
  •    Consequences of Chronic Bacterial Infections on Development of Cancer
  •    Detection of Novel Genomic Polymorphism in Acute Lymphoblastic Leukemia by Random Amplified Polymorphic DNA Analysis
  •    Molecular Analysis of RAPD-PCR Genomic Patterns in Age Related Acute Myeloid Leukemia
  •    Identification of Genomic Markers by RAPD-PCR Primer in Leukemia Patients
How to cite this article:

Mohammed A. Ibrahim , 2010. Perspective of DNA Methylation in Cancer Research. International Journal of Cancer Research, 6: 188-201.

DOI: 10.3923/ijcr.2010.188.201


29 July, 2010
Really I find interest in your abstract.But sir I want to know what are those bacteria which change the pattern of DNA.I am M.Sc in zoology with specialization in Animal Physiology and Biochemistry with 72 percent.
29 July, 2010
Mohammed A. Ibrahim:

Dear Barman, Thanks for your interest, open the fulltext PDF and have a look at table 3 you will find the bacteria and the references, they include: H. pylori, Salmonella typhi, Mycoplasma and Streptococcus bovis. Regards M. Ibrahim





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