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Perspective of DNA Methylation in Cancer Research |
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Mohammed A. Ibrahim |
Abstract:
DNA methylation is one of three epigenetic mechanisms which has seen increasing
interest among cancer researchers, as changes in DNA methylation have emerged
as one of the most consistent molecular aberrations in various neoplasms. Aberration
of DNA methylation have been identified in the global genomic DNA (hyper or
hypo methylation) or within CpG islands in promoter regions of tumor suppressor
genes. Several types of bacteria which cause chronic infections are associated
with cancer development and chronic infection of Helicobacter pylori might give
rise to changes in pattern of DNA methylation. Recent discoveries are giving
evidence in the involvement of aberration in DNA methylation in conferring resistance
to antitumor agents, and efforts of molecular biologists are directed to overcome
this problem by introducing new epigenomic drugs which reform DNA methylation,
and help in tumor therapy. Another interesting prospective of current research
in DNA methylation is the possibility of development molecular markers for early
detection of tumors. The objectives of this article are to review various recent
progress of DNA methylation in cancer research.
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How to cite this article:
Mohammed A. Ibrahim , 2010. Perspective of DNA Methylation in Cancer Research. International Journal of Cancer Research, 6: 188-201.
DOI: 10.3923/ijcr.2010.188.201
URL: https://scialert.net/abstract/?doi=ijcr.2010.188.201
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| COMMENTS |
29 July, 2010
ANAMIKA BARMAN:
Really I find interest in your abstract.But sir I want to know what are those bacteria which change the pattern of DNA.I am M.Sc in zoology with specialization in Animal Physiology and Biochemistry with 72 percent. |
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29 July, 2010
Mohammed A. Ibrahim:
Dear Barman,
Thanks for your interest, open the fulltext PDF and have a look at table 3 you will find the bacteria and the references, they include: H. pylori, Salmonella typhi, Mycoplasma and Streptococcus bovis.
Regards
M. Ibrahim |
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