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International Journal of Cancer Research
  Year: 2008 | Volume: 4 | Issue: 1 | Page No.: 20-27
DOI: 10.3923/ijcr.2008.20.27
 
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Cytotoxic Activity of Pereskia bleo (Cactaceae) Against Selected Human Cell Lines

Sri Nurestri Abd Malek, Norhanom Abdul Wahab, Hashim Yaacob, Sim Kae Shin, Hong Sok Lai, Lee Guan Serm and Syarifah N.S.A. Rahman

Abstract:
Pereskia bleo (Cactaceae) was investigated for its cytotoxic effect against selected human cell lines, namely the Human Nasopharyngeal Epidermoid Carcinoma Cell Line (KB), Human Cervical Carcinoma Cell Line (CasKi), Human Colon Carcinoma Cell Line (HCT 116), Hormone-Dependent Breast Carcinoma Cell Line (MCF7) and non-cancer Human Fibroblast Cell Line (MRC-5) by using an in vitro neutral red cytotoxicity assay. All the crude methanolic and its fractionated extracts (hexane, ethyl acetate and water) exert no damage to the MRC-5 normal cells. The crude methanol extract and the ethyl acetate fraction of Pereskia bleo possessed notably high cytotoxic effect against KB cells with IC50 values of 6.5 and 4.5 μg mL-1, respectively. Four compounds isolated from the ethyl acetate fraction of Pereskia bleo were identified as phytol, β-sitosterol, 2,4-di-tert-butylphenol and vitamin E. All four compounds have not been reported for this plant.
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How to cite this article:

Sri Nurestri Abd Malek, Norhanom Abdul Wahab, Hashim Yaacob, Sim Kae Shin, Hong Sok Lai, Lee Guan Serm and Syarifah N.S.A. Rahman, 2008. Cytotoxic Activity of Pereskia bleo (Cactaceae) Against Selected Human Cell Lines. International Journal of Cancer Research, 4: 20-27.

DOI: 10.3923/ijcr.2008.20.27

URL: https://scialert.net/abstract/?doi=ijcr.2008.20.27

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