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International Journal of Cancer Research
  Year: 2008 | Volume: 4 | Issue: 3 | Page No.: 103-109
DOI: 10.3923/ijcr.2008.103.109
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Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia

A.S. Nor Aini, A. Merrina, J. Stanslas and S. Sreeramanan

In vitro studies were carried out to evaluate the cytotoxic potential of three selected forest herbaceous species: Tectaria singaporeana (TS), Blechnum orientale (BO) and Tacca integrifolia (TCI). Methanol/methylene chloride extracts of three plant parts viz. leaves, roots and stems were assessed for their cytotoxic potential against human breast cancer cells (MCF-7wt.). Screening of these extracts was done using the microculture, followed by tetrazolium assay after a period of 72 h. There were significant differences between different parts of plants and dilution levels in terms of cytotoxicity, with roots and concentration of 100 μg mL-1 showing the highest cell mortality of 19.58 and 36.59%, respectively. However, the leaves and the stems of all three plant species did not induce any cytotoxic activity on the cells. Overall, the most promising material (IC50 <100 μg mL-1) were the methanolic extracts from the roots of all three plants. Tectaria singaporeana showed the highest cytotoxic potential with an IC50 value of 28.57 ± 11.74 μg mL-1 followed by Blechnum orientale, 32.07 ± 7.85 μg mL-1 and Tacca integrifolia, 95.03 ± 17.49 μg mL-1. From this study, the extracts of these plants may prove to be useful in cancer treatment and prevention.
PDF Fulltext XML References Citation Report Citation
  •    In vitro Cytotoxic Activity of Vatica diospyroides Symington Type LS Root Extract on Breast Cancer Cell Lines MCF-7 and MDA-MB-468
  •    Evaluation of Anti Cancer Activity of Polyherbal Formulation
  •    In vitro Cytotoxic Evaluation of Hugonia mystax Linn. Leaf and Stem Bark Extracts
  •    In vitro Cytotoxic Activity of Dendrophthoe falcata on Human Breast Adenocarcinoma Cells-MCF-7
How to cite this article:

A.S. Nor Aini, A. Merrina, J. Stanslas and S. Sreeramanan, 2008. Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research, 4: 103-109.

DOI: 10.3923/ijcr.2008.103.109






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