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International Journal of Cancer Research

Year: 2007 | Volume: 3 | Issue: 1 | Page No.: 13-24
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Authors

K. Nirmala

T. Prasanna Krishna

K. Polasa

Keywords

Research Article

Protective Effect of Ginger Against Benzo(a)pyrene Induced DNA Damage

K. Nirmala, T. Prasanna Krishna and K. Polasa
The present study involved the recognition of the effect of aqueous extract of ginger to prevent carcinogen-induced genotoxicity in human peripheral blood lymphocytes ex-in vivo by single cell gel electrophoresis technique in the presence and absence of ginger extract. Blood was obtained from 30 human volunteers of which 10 were apparently normal male non-smokers, 10 male smokers and 10 females. Aqueous ginger extract at three concentrations namely 2.5, 5 and 10 μg were tested for protective effect against B(a)P (300 μM) induced DNA damage. The results indicated that DNA damage expressed as comet ratio was decreased in samples treated with only B(a)P. When ginger extracts were present in incubation mixtures the comet ratios have increased depending on the dose of ginger extract. At the highest concentration of ginger extract namely 10 μg, the comet ratios were similar to their respective controls demonstrating the protective effect of ginger on carcinogen induced DNA damage.
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