In vitro Antitumour Activity of Solanum aculeastrum Berries on Three Carcinoma Cells

Research Article

In vitro Antitumour Activity of Solanum aculeastrum Berries on Three Carcinoma Cells

S. Koduru, D.S. Grierson, M. van de Venter and A.J. Afolayan

Solanum aculeastrum is a medicinal plant used by the traditional healers of the Eastern Cape of South Africa, for the treatment of cancers. The antiproliferative activities of this plant were studied in vitro using three human tumour cell lines (HeLa, MCF7 and HT29). Methanolic extracts of the fruits had the highest antiproliferative activity with IC₅₀ between 17.1 and 41.9 μg mL^-1 while the activities of their aqueous extracts ranged between 27.9 and 48.5 μg mL^-1. The leaf extracts had no anticancer activity under the experimental conditions tested. Overall, the HeLa and MCF7 cell lines were much more sensitive to both extracts than HT29 cells.

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S. Koduru, D.S. Grierson, M. van de Venter and A.J. Afolayan, 2006. In vitro Antitumour Activity of Solanum aculeastrum Berries on Three Carcinoma Cells. International Journal of Cancer Research, 2: 397-402.

DOI: 10.3923/ijcr.2006.397.402

URL: https://scialert.net/abstract/?doi=ijcr.2006.397.402

International Journal of Cancer Research

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Authors

S. Koduru

D.S. Grierson

M. van de Venter

A.J. Afolayan

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Research Article

In vitro Antitumour Activity of Solanum aculeastrum Berries on Three Carcinoma Cells

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