Science Alert
 
Blue
   
Curve Top
International Journal of Cancer Research
  Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 267-276
DOI: 10.3923/ijcr.2006.267.276
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

QSAR Modeling of Some 2-methoxy Acridones: Cytotoxic Agents in Multi Drug Resistant Cells

N.S.H.N. Moorthy and P. Trivedi

Abstract:
In pursuit of effective anticancer molecules that can overcome resistance problems, a series of cytotoxic N10 substituted 2-methoxy acridone analogues were subjected to quantitative structure activity relationship analysis employing 2D molecular descriptors calculated from QSAR software Dragon. Multiple linear regression analysis of the data following a stepwise technique resulted in statistically significant triparametric models with good predictive power (r>0.9, q2>0.8). The results of the study suggest that flexibility of substituent sidechain and four membered methylene bridges between the acridone nucleus and substituents enhances the cytotoxic potency of 2 methoxy acridones. Further, the generated QSAR models also indicate that bulky substituents and the presence of sulfur atoms are disfavored whereas heteroatoms in the molecular extremity are favored for cytotoxic activity.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    2D Qsar Study of 7-Methyljuglone Derivatives: An Approach to Design Anti Tubercular Agents
  •    Quantitative Structure Activity Relationship Analysis of N-(mercaptoalkanoyl)- and [(acylthio)alkanoyl] Glycine Derivatives as ACE Inhibitors
How to cite this article:

N.S.H.N. Moorthy and P. Trivedi, 2006. QSAR Modeling of Some 2-methoxy Acridones: Cytotoxic Agents in Multi Drug Resistant Cells. International Journal of Cancer Research, 2: 267-276.

DOI: 10.3923/ijcr.2006.267.276

URL: https://scialert.net/abstract/?doi=ijcr.2006.267.276

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 



Curve Bottom