Research Article

In vitro Cytotoxic Evaluation of Hugonia mystax Linn. Leaf and Stem Bark Extracts

Singaram Anandakumar and Natchimuthu Karmegam

In the present study, the methanol extracts of Hugonia mystax Linn. leaves and stem bark were tested for cytotoxic effect against three different human cancer cell lines, HeLa cervical cancer cell line, MCF-7 human breast adenocarcinoma cell line and A-549 human lung adenocarcinoma epithelial cell line, in comparison with normal vero cell line by MTT assay. Results revealed that the methanolic extracts of leaves stem bark exhibited cytotoxicity towards the cancerous cell lines. CTC₅₀ concentration of 228.12, 181.01, 343.75 and 875.0 μg mL^-1 against HeLa, MCF-7, A-549 and vero cell lines was recorded. Methanolic stem bark extract showed the lower CTC₅₀ concentration against HeLa and MCF-7 cell lines and higher CTC₅₀ concentration against A-549 and vero cell lines. The results indicated us the feasible anticancer nature of the leaf and bark methanolic crude extracts of H. mystax.

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Singaram Anandakumar and Natchimuthu Karmegam, 2011. In vitro Cytotoxic Evaluation of Hugonia mystax Linn. Leaf and Stem Bark Extracts. International Journal of Botany, 7: 300-304.

DOI: 10.3923/ijb.2011.300.304

URL: https://scialert.net/abstract/?doi=ijb.2011.300.304

International Journal of Botany

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Authors

Singaram Anandakumar

Natchimuthu Karmegam

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Research Article

In vitro Cytotoxic Evaluation of Hugonia mystax Linn. Leaf and Stem Bark Extracts

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