Abeer E. Abdelwahab
Department of Medical Biotechnology,Genetic Engineering and Biotechnology Research Institute (GEBRI),Mubarak City for Scientific Research and Technology Applications (MUCSAT),Alexandria, Egypt
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How to cite this article
Abeer E. Abdelwahab, 2009. Immunological and Molecular Diagnosis of Mycobacterium tuberculosis Between two Environmentally Different Regions. Current Research in Tuberculosis, 1: 1-8.
URL: https://scialert.net/abstract/?doi=crt.2009.1.8
URL: https://scialert.net/abstract/?doi=crt.2009.1.8
kaivaramsarada Reply
its good to see this abstract, but what about the latent tuberculosis infected people. bcs of the pollution they r prone to T.B or they resist?
Abeer Abd El- Wahab, ( the author) Reply
Reply:
Patients with latent tuberculosis are not infectious, and it is not possible to get TB from someone with latent tuberculosis. The main risk is that approximately 10% of these patients will go on to develop active tuberculosis at a later stage of their life.
There are currently two γ-interferon tests available to identify patients with latent tuberculosis:
• ELISPOT (done on my published article)
• QuantiFERON-TB
Prof(Dr) Jogenananda Pramanik.MD Reply
Like several other researchers, Abeer E. Abdelwahab once again confirmed the power of the molecular techniques and showed it to be more sensitive than the traditional methods and the PCR assay was more accurate than the ELISpot assay.However,the Gold standard test for tuberculosis is the age old culture method because PCR assay picks up the DNA fragment of dead bacilli and gives false positive results in some situation.PCR assay is expensive and not available at the resource poor set up in most of the developing or under developed countries and diagnostic delay continues to be a never-ending problem for the clinicians in the field situations. Therefore,during my MD thesis work,I described an innovative culture method to expedite bacilli cultivation in modified solid and liquid media which is proved to be useful for early and accurate diagnosis of tuberculosis in any resource poor setting in peripheral clinics.
References:
10.1136/bmj.326.7395.909