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Biotechnology
  Year: 2008 | Volume: 7 | Issue: 4 | Page No.: 623-629
DOI: 10.3923/biotech.2008.623.629
 
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Brief Naturalistic Stressors Cause Shift of TH1 to TH2 Cytokine Response and Increase Disease Susceptibility

Mahbub-E-Sobhani , N. Haque, A.T.M.K. Islam, U. Salma, A. Ahmed, I.J. Mukti and A.K.M.F. Haque

Abstract:
In this study, a typical psycho-neuro-endocrino-immune network has been developed in which, Corticotrophin Releasing Hormone (CRH), adrenocorticotrophic hormone (ACTH), glucocorticoids (GC), β-endorphin (β-end) and met-enkephalin (Met-enk) are found as important endocrine components and T cells, B cells, monocytes/macrophages, Natural Killer (NK) cells and their cytokines that is tumor necrosis factor-α (TNF-α), interferon gamma (IFN-γ) and interleukins such as IL-1, IL-2, IL-4, IL-6, IL-10, IL-12 etc., are found as important immune components. Finally, it has been shown that, brief naturalistic stressors have different immune modulatory activities such as, cause shift of TH1 to TH2 cytokine response which is harmful to one`s homeostasis and increase disease susceptibility.
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How to cite this article:

Mahbub-E-Sobhani , N. Haque, A.T.M.K. Islam, U. Salma, A. Ahmed, I.J. Mukti and A.K.M.F. Haque, 2008. Brief Naturalistic Stressors Cause Shift of TH1 to TH2 Cytokine Response and Increase Disease Susceptibility. Biotechnology, 7: 623-629.

DOI: 10.3923/biotech.2008.623.629

URL: https://scialert.net/abstract/?doi=biotech.2008.623.629

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