Research Article

In vitro Antibacterial Activity of an Active Metabolite Isolated from Streptomyces Species

M. Zakir Sultan, Naznin Ara Khatune, Zakia Sultana Sathi, Md. Shah Alam Bhuiyan, M. Golam Sadik, M. Akteruzzaman Choudury, M. A. Gafur and Md. Aziz Abdur Rahman

The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow antibiotic metabolite by chromatographic technique and was identified as 2 N-butanamide 3-methyl 4-methoxy 5-β-L-arabinosyl propanophenone (MZ-4) on the basis of spectral data. The compound exhibited significant antibacterial activity against five gram positive and nine gram negative bacteria when compared with standard Kanamycin antibiotic. The zone of inhibition were observed between 17 to 20 mm. The minimum inhibitory concentration (MIC) of the compound was determined against four gram positive and gram negative bacteria and the values were found between 32 and 64 μg ml^-1.

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M. Zakir Sultan, Naznin Ara Khatune, Zakia Sultana Sathi, Md. Shah Alam Bhuiyan, M. Golam Sadik, M. Akteruzzaman Choudury, M. A. Gafur and Md. Aziz Abdur Rahman, 2002. In vitro Antibacterial Activity of an Active Metabolite Isolated from Streptomyces Species. Biotechnology, 1: 100-106.

DOI: 10.3923/biotech.2002.100.106

URL: https://scialert.net/abstract/?doi=biotech.2002.100.106

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Authors

M. Zakir Sultan

Naznin Ara Khatune

Zakia Sultana Sathi

Md. Shah Alam Bhuiyan

M. Golam Sadik

M. Akteruzzaman Choudury

M. A. Gafur

Md. Aziz Abdur Rahman

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Research Article

In vitro Antibacterial Activity of an Active Metabolite Isolated from Streptomyces Species

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