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Asian Journal of Scientific Research
  Year: 2011 | Volume: 4 | Issue: 1 | Page No.: 62-70
DOI: 10.3923/ajsr.2011.62.70
 
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Effects of Selected Antioxidant Vitamins on Lipid Profile in Early Pregnancy

O.I. Iribhogbe, A. Aigbiremolen, U. Akpamu, J.E. Emordi and E.O. Nwoke

Abstract:
The purpose of this study is to evaluate the effects of vitamin A, C and E supplementation on lipid profile in early pregnancy. A total of 85 adult female wistar albino rats weighting 225-300 g were used and randomly grouped into 5 groups (2 control groups of five rats each, 3 test groups with 5 sub- groups of 5 rats each). After, pregnancy was confirmed, the control groups were administered distilled water and tween 80 respectively, while test groups A, C and E received vitamin A, C and E supplements, respectively. At the end of the 11th day of the experiment, blood samples were collected and TC (total cholesterol), TG (Triglyceride), LDL-C (low density lipoprotein cholesterol and HDL-C (high density lipoprotein cholesterol) were assayed using standard procedure. The test group had significantly increased TC, LDL- C and HDL- C but decreased TG levels following vitamin A administration when compared with control (p<0.05). The group supplemented with vitamin C also had significantly higher TC, TG and LDL- C and unchanged HDL-C compared with control (p<0.05). The group supplemented with vitamin E had a non significant TC levels, a significantly increased TG and HDL- C and a significantly reduced LDL- C levels (p<0.05). Based on results observed, we suggest that, in pregnancy, dietary supplementation with Vitamin A and E may be cardioprotective. This is because vitamin A and E significantly increase HDL- C, although this is accompanied by increase of other serum lipid component. Vitamin C, however was not beneficial.
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How to cite this article:

O.I. Iribhogbe, A. Aigbiremolen, U. Akpamu, J.E. Emordi and E.O. Nwoke, 2011. Effects of Selected Antioxidant Vitamins on Lipid Profile in Early Pregnancy. Asian Journal of Scientific Research, 4: 62-70.

DOI: 10.3923/ajsr.2011.62.70

URL: https://scialert.net/abstract/?doi=ajsr.2011.62.70

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