Submit Manuscript

American Journal of Food Technology

Year: 2010 | Volume: 5 | Issue: 6 | Page No.: 376-384
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 199

Authors

E.E.J. Iweala

O. Obidoa

Keywords

Research Article

Studies on Some Biochemical and Histological Changes Associated with Long Term Consumption of Leaves of Ocimum gratissimum L. in Male Rats

E.E.J. Iweala and O. Obidoa
This study investigated changes in some biochemical and histological parameters in male rats fed with an Ocimum gratissimum-supplemented diet for six months. Biochemical parameters studied include serum protein, cholesterol, lipid peroxidation, glutathione-S-transferase, superoxide dismutase, alanine transaminase, aspartate transaminase, alkaline phosphatase, haemoglobin and white blood cells. The histological characteristics of tissue sections of liver, intestines and testes were also examined. The weight of the animals increased significantly (p<0.05) over the control. There were also significant reductions (p<0.05) in serum protein, cholesterol, lipid peroxidation and haemoglobin in the animals. Superoxide dismutase was also significantly increased (p<0.05) while the changes in glutathione-S-transferase, alanine transaminase, aspartate transaminase and alkaline phosphatase were not significant. White blood cell count was significantly increased (p<0.05). Histological changes in the intestines revealed the presence of increased villi and larger globlet cells. The testes also showed increased number of sperm cells and spermatogonia while there were no visible changes in the histology of the liver.
PDF Fulltext XML References Citation

Related Articles

Analgesic and Hepatoprotective Activity of Methanolic Leaf Extract of Ocimum gratissimum (L.)
Biochemical, Haematological and Histological Effects of Dietary Supplementation with Leaves of Gnetum africanum Welw. on Paracetamol-induced Hepatotoxicity in Rats
Effect of a Long Term Consumption of a Diet Supplemented with Leaves of Gongronema latifolium Benth. on Some Biochemical and Histological Parameters in Male Albino Rats
Biochemical and Histological Changes Associated with Long Term Consumption of Gnetum africanum Welw. Leaves in Rats
Some Biochemical, Haematological and Histological Responses to a Long Term Consumption of Telfairia occidentalis-Supplemented Diet in Rats

Leave a Comment

Your email address will not be published. Required fields are marked *