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Effects of Anti-erectile Dysfunction Drug on some Key Tissues in Healthy Male Rats |
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J.K. Akintunde,
J.A. Ajiboye,
E.O. Siemuri,
S.B. Oyelowo,
O.J. Sunday,
E.O. Abam and A.E. Irondi |
Abstract:
Erectile Dysfunction (ED) occurs in folk men which poses great threat to couples
awaiting children. The liver is one of the most vital organs involved in drug
detoxification process. However, the concomitant toxic effects of Viagra on
liver with other tissues are unknown. The present study was aimed to elucidate
the effects of therapeutic doses of orally administered Viagra on the antioxidant
defense status of liver, kidney, spleen and lung tissues in healthy rats. Wistar
healthy albino Rats were orally administered with various therapeutic doses
(20 mg kg-1 b.wt.) of Sildenafil citrate (viagra) for 4 weeks exhibited
mild hepatocyte necrosis, periportal cellular infiltration by mononuclear cells
and no visible lesions in kidney cells. This is accompanied with non-significant
elevated plasma alanine amino transaminase (ALT) and aspartic amino transaminase
(AST) levels, decreased hepatic MDA level and increased levels of MDA in kidney,
spleen and lung. GSH was increased in liver, kidney, spleen and decreased in
lung. CAT and SOD activity were elevated in liver, kidney and spleen. Lung showed
high activity of SOD and low activity of CAT. Hence, administration of Viagra
potentiates both enzymatic and non-enzymatic antioxidants in liver, kidney and
spleen while it may promote inflammatory response in male rats. The present
study provides evidence for stabilizing antioxidant defense systems in liver,
kidney, spleen and may be a contributory factor for lung inflammatory responses.
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How to cite this article:
J.K. Akintunde, J.A. Ajiboye, E.O. Siemuri, S.B. Oyelowo, O.J. Sunday, E.O. Abam and A.E. Irondi, 2013. Effects of Anti-erectile Dysfunction Drug on some Key Tissues in Healthy Male Rats. American Journal of Drug Discovery and Development, 3: 32-46.
DOI: 10.3923/ajdd.2013.32.46
URL: https://scialert.net/abstract/?doi=ajdd.2013.32.46
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