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Asian Journal of Biological Sciences
  Year: 2011 | Volume: 4 | Issue: 3 | Page No.: 282-290
 
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Evaluation of Antiangiogenic, Cytotoxic and Antioxidant Effects of Syzygium aromaticum L. Extracts

Abdalrahim F.A. Aisha, Zeyad D. Nassar, Mohammad J. Siddiqui, Khalid M. Abu-Salah, Salman A. Alrokayan, Zhari Ismail and Amin Malik Shah Abdul Majid

Abstract:
This study aims to investigate the total phenolics content, antioxidant, antiangiogenic and cytotoxic effects of three extracts from the leaves, stem and bark of Syzygium aromaticum L (SA). The motivation behind this study was to highlight the importance of other parts of SA than the flower buds as botanical sources of bioactive materials. The total phenolics were determined in a colorimetric method using gallic acid as a standard, the antioxidant effects were studied in DPPH assay, antiangiogenic effects were investigated in vitro on rat aortic rings and the cytotoxic properties were evaluated in XTT assay on endothelial cells, breast and colon cancer cells. The extracts were found to contain high levels of total phenolics with strong antioxidant activity. Significant inhibition of the blood vessels outgrowth was also obtained in the angiogenesis model. Cytotoxicity testing on three cell lines indicated high cytotoxic effects with the highest activity obtained on the estrogen dependent breast cancer cells. The presented results illustrate the importance of SA leaves, stems and bark as good sources of phenolics-rich extracts. Further studies are required to investigate the antiestrogenic and the potential anti breast cancer activity of SA extracts especially the stem extract and to identify and purify the active constituents.
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How to cite this article:

Abdalrahim F.A. Aisha, Zeyad D. Nassar, Mohammad J. Siddiqui, Khalid M. Abu-Salah, Salman A. Alrokayan, Zhari Ismail and Amin Malik Shah Abdul Majid, 2011. Evaluation of Antiangiogenic, Cytotoxic and Antioxidant Effects of Syzygium aromaticum L. Extracts. Asian Journal of Biological Sciences, 4: 282-290.

URL: https://scialert.net/abstract/?doi=ajbs.2011.282.290

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