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Anti-inflammatory and Antioxidant Activities of a Fraction I1 of Male Inflorescences of Borassus aethiopum Mart (Arecaceae) |
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J. Sakande,
E. Kabre,
M. Lompo,
E. Pale,
J.B. Nikiema,
O.G. Nacoulma,
M. Sawadogo and I.P. Guissou |
Abstract:
In previous studies, using a bioassay-guided fractionation procedure; five
fractions (E1F1, E2F2, E3F3, E4F4 and E5F5) from powdered Borassus aethiopum
male inflorescences were extracted. Among these, the dichloromethane methanol
extract E2F2 was found to exert significant anti-inflammatory and antipyretic
activities and pro apoptotic effect. It seemed important to pursue the investigations
to understand the mechanism of the anti-inflammatory activity. The anti-inflammatory
activity was studied, C Reactive Protein (CRP) level in mice blood was immunoturbidimetry
after inflammation induction and antioxidant activity was studied using 1,1
diphenyl picrylhydrazyl (DPPH). Phytochemical screening was carried out according
to the methodology for chemical analysis for vegetable drugs. Among 3 fractions
(I1; I2, I3) of E2F2, I1 was the most active with a percentage of inhibition
(PI) of 80%. This anti-inflammatory activity was twice high than indometacin
(PI = 40%). The I1 fraction cause significant decline of concentration of CRP
compared with indometacin. The radical scavenging activities of I1 were approximately
4 times lower than ascorbic acid. Phytochemical analyses of Borassus aethiopum
extracts revealed the presence of terpenoids, steroids and saponins which all
have been shown to be potent anti-inflammatory and antioxidants. The present
study confirmed the anti-inflammatory and antioxidant potential of Borassus
aethiopum extracts with results comparable with those of standard compounds
such as indometacin. Further studies are needed to isolate, purify and identify
the chemical structure of the compounds responsible for anti-inflammatory and
antioxidant activity.
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How to cite this article:
J. Sakande, E. Kabre, M. Lompo, E. Pale, J.B. Nikiema, O.G. Nacoulma, M. Sawadogo and I.P. Guissou, 2013. Anti-inflammatory and Antioxidant Activities of a Fraction I1 of Male Inflorescences of Borassus aethiopum Mart (Arecaceae). American Journal of Biochemistry and Molecular Biology, 3: 101-109.
DOI: 10.3923/ajbmb.2013.101.109
URL: https://scialert.net/abstract/?doi=ajbmb.2013.101.109
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