• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. American Journal of Biochemistry and Molecular Biology
  2. Vol 2 (2), 2012
  3. 67-81
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

American Journal of Biochemistry and Molecular Biology

Year: 2012 | Volume: 2 | Issue: 2 | Page No.: 67-81
DOI: 10.3923/ajbmb.2012.67.81

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 494

Search


Authors


B. Ogunlade


L.C.  Saalu

L.C. Saalu

LiveDNA: 234.30960

O.S. Ogunmodede


G.G. Akunna


O.A. Adeeyo


G.O. Ajayi


Keywords


  • Alcohol-induced liver damage
  • oxidative stress
  • Allium cepa
  • antioxidants
Research Article

The Salutary Role of Allium cepa Extract on the Liver Histology, Liver Oxidative Status and Liver Marker Enzymes of Rabbits Submitted to Alcohol-induced Toxicity

B. Ogunlade, L.C. Saalu L.C.  Saalu's LiveDNA, O.S. Ogunmodede, G.G. Akunna, O.A. Adeeyo and G.O. Ajayi
Alcohol is currently recognized as the most prevalent known cause of abnormal human health. Furthermore, the liver remains the most commonly affected organs following alcohol abuse. The effect of Allium cepa against alcohol-induced hepatic damage in rabbits was investigated in the present study. Rabbits were divided into four groups; The Allium cepa-alone group received physiological saline 5 mL kg-1 b.wt., daily per oral (p.o) for 60 days followed by Allium cepa 100 mg kg-1 b.wt., daily p.o for another 60 days. The alcohol-alone group was given alcohol 5 mg kg-1 b.wt., daily p.o for 60 days followed by saline 5 mL kg-1 b.wt., daily p.o for another 60 days. The alcohol plus Allium cepa group were similarly given alcohol, but had Allium cepa 100 mg kg-1 b.wt, daily p.o post-treatment for another 60 days. Another group of rabbits were given peanut oil (the vehicle) 100 mg kg-1 b.wt., daily p.o, for 60 days, after saline 5 mL kg-1 b.wt., daily p.o for 60 days to serve as the control. The gross anatomical parameters of the liver and liver histology were assessed. Liver oxidative stress was evaluated by liver Superoxide dismutase (SOD), catalase (CAT), Glutathione Peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA) assays. In addition, the activities of the biomarker enzymes of the liver (alanine transaminase, aspartate transaminase, alkaline phosphatase and gamma-glutamyl transpeptidase) were assayed. An assessment of the histological profiles of the liver showed a derangement of the liver cytoarchitecture following alcohol abuse and a marked improvement was observed after Allium cepa administration. Similarly, Allium cepa improved the reduction of antioxidant parameters (SOD, CAT, GPx and GSH) and the increased MDA and serum hepatic markers levels caused by alcohol ingestion. It was concluded that Allium cepa may offer protection against free radical mediated oxidative stress of rabbits with alcohol-induced hepatotoxicity.
PDF Fulltext XML References Citation

How to cite this article

B. Ogunlade, L.C. Saalu, O.S. Ogunmodede, G.G. Akunna, O.A. Adeeyo and G.O. Ajayi, 2012. The Salutary Role of Allium cepa Extract on the Liver Histology, Liver Oxidative Status and Liver Marker Enzymes of Rabbits Submitted to Alcohol-induced Toxicity. American Journal of Biochemistry and Molecular Biology, 2: 67-81.

DOI: 10.3923/ajbmb.2012.67.81

URL: https://scialert.net/abstract/?doi=ajbmb.2012.67.81

Related Articles

Effect of Oleo-gum-resin on Ethanol-induced Hepatotoxicity in Rats
Cytotoxic Effects of Multiple N-nitrosamines in Human Liver Cell Line Hep2G: Possible Mechanisms of Action
The Effect of Lacidipine on Indomethacin Induced Ulcers in Rats
The Incriminating Role of Reactive Oxygen Species in Idiopathic Male Infertility: An Evidence Based Evaluation
An Evaluation of Influence of Citrus paradisi Seed Extract on Doxorubicin-Induced Testicular Oxidative Stress and Impaired Spermatogenesis
Ethanolic Seed Extract of Grapefruit (Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart
The Effect of Unilateral Varicocele on the Contralateral Testicular Histo-Morphology and Function in Rattus norvegicus
Grapefruit Seed Extract Moderates Morphologic, Functional and Biochemical Evidences of Epidoxorubicin-Induced Testicular Toxicity

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved