Submit Manuscript

American Journal of Biochemistry and Molecular Biology

Year: 2012 | Volume: 2 | Issue: 4 | Page No.: 227-234
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 1076

Search

Authors

Friday E. Uboh

Friday E. Uboh

Itoro F. Usoh

Promise Nwankpa

Godwin O. Obochi

Keywords

Research Article

Effect of Oral Exposure to Nitrocellulose Thinner on Haematological Profiles of Male Albino Wistar Rats

Friday E. Uboh Friday E. Uboh's LiveDNA, Itoro F. Usoh, Promise Nwankpa and Godwin O. Obochi
Haematological profiles provide important information about the internal environment of a given organism. In this present study, varying concentrations (10, 15, 20 and 25 mg kg-1) of nitrocellulose thinner were orally administered to male albino rats, as single daily dosage for 30 days, to assess the haematological changes associated with oral exposure to solvent. The results showed a significant (p<0.05) dose-dependent decrease in Red Blood Cells (RBC) count, haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), neutrophils and increase in total White Blood Cells (WBC), platelets and lymphocytes, compared to the control. However, there was no significant (p>0.05) difference in the changes in the level of these parameters in rats exposed to 10 mg kg-1 when compared to the rats exposed to 15 mg kg-1 and 20 mg kg-1 when compared to the rats exposed to 25 mg kg-1 of the solvent. The results recorded in this present study suggested that exposure to nitrocellulose thinner’s constituents, or their metabolites, may be a risk factor for haematotoxicity in mammals. Hence, the haematotoxic properties of nitrocellulose thinner are reported in the study.
PDF Fulltext XML References Citation

Related Articles

Plasma Concentration of Platelet Factor 4: As an Evidence of Platelet Activation in Parasitic Infections
Gongronema latifolium Crude Leaf Extract Reverses Alterations in Haematological Indices and Weight-loss in Diabetic Rats
Phytochemistry and Heamatological Potential of Ethanol Seed Leaf and Pulp Extracts of Carica papaya (Linn.)
Comparative Study of Some Haematological Parameters in Rats Following Ingestion of Crude Oil (Nigerian Bonny Light), Petrol, Kerosene and Diesel
Hematologic and Hepatic Enzyme Alterations Associated with Acute Administration of Antiretroviral Drugs
The Effects of Aqueous Ocimum gratissimum Leaf Extract on Some Biochemical and Hematological Parameters in Male Mice

Comments

muhammed Reply

thanks
the research was perfect

Leave a Comment

Your email address will not be published. Required fields are marked *