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Effect of Oral Exposure to Nitrocellulose Thinner on Haematological Profiles of Male Albino Wistar Rats |
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Friday E. Uboh,
Itoro F. Usoh,
Promise Nwankpa and Godwin O. Obochi |
Abstract:
Haematological profiles provide important information about the internal environment
of a given organism. In this present study, varying concentrations (10, 15,
20 and 25 mg kg-1) of nitrocellulose thinner were orally administered
to male albino rats, as single daily dosage for 30 days, to assess the haematological
changes associated with oral exposure to solvent. The results showed a significant
(p<0.05) dose-dependent decrease in Red Blood Cells (RBC) count, haemoglobin
(Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular
Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), neutrophils
and increase in total White Blood Cells (WBC), platelets and lymphocytes, compared
to the control. However, there was no significant (p>0.05) difference in
the changes in the level of these parameters in rats exposed to 10 mg kg-1
when compared to the rats exposed to 15 mg kg-1 and 20 mg kg-1
when compared to the rats exposed to 25 mg kg-1 of the solvent. The
results recorded in this present study suggested that exposure to nitrocellulose
thinner’s constituents, or their metabolites, may be a risk factor for
haematotoxicity in mammals. Hence, the haematotoxic properties of nitrocellulose
thinner are reported in the study.
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How to cite this article:
Friday E. Uboh, Itoro F. Usoh, Promise Nwankpa and Godwin O. Obochi, 2012. Effect of Oral Exposure to Nitrocellulose Thinner on Haematological Profiles of Male Albino Wistar Rats. American Journal of Biochemistry and Molecular Biology, 2: 227-234.
DOI: 10.3923/ajbmb.2012.227.234
URL: https://scialert.net/abstract/?doi=ajbmb.2012.227.234
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| COMMENTS |
01 April, 2019
muhammed:
thanks
the research was perfect |
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