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  1. American Journal of Biochemistry and Molecular Biology
  2. Vol 2 (3), 2012
  3. 195-199
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American Journal of Biochemistry and Molecular Biology

Year: 2012 | Volume: 2 | Issue: 3 | Page No.: 195-199
DOI: 10.3923/ajbmb.2012.195.199

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Authors


Amir  Ghaemi

Amir Ghaemi

LiveDNA: 98.7273

Kasra Hamdi


Mansoureh Togha


Hadi Kazemi


Ali Gorji


Keywords


  • matrix metallo proteinase proteins
  • tissue inhibitors of metalloproteinases
  • Multiple sclerosis
  • therapeutic target
Commentary

Tissue Inhibitors of Matrix Metalloproteinase-3, Potential Therapeutic Target against Multiple Sclerosis

Amir Ghaemi Amir  Ghaemi's LiveDNA, Kasra Hamdi, Mansoureh Togha, Hadi Kazemi and Ali Gorji
The Matrix Metalloproteinase Proteins (MMPs) comprise a large group of endoproteinases that cleave most, if not all, components of the extracellular matrix. The activities of MMPs are modulated by manipulation in the levels of natural MMP inhibitors, the “Tissue Inhibitors of Metallo Proteinases” (TIMPs). In a pathological processes of Multiple Sclerosis (MS), the MMP-2 and 9 (Gelatinase) are over expressed and balance of TIMP and MMP expression is perturbed, leading to locally increased proteolytic activity of Gelatinase and uncontrolled degradation of the Blood Brain Barrier (BBB) and myelin basic protein. Therefore, Gelatinase are the main mediators in the evolution of MS and TIMP has been proposed as a novel therapeutic target for MS therapy.
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How to cite this article

Amir Ghaemi, Kasra Hamdi, Mansoureh Togha, Hadi Kazemi and Ali Gorji, 2012. Tissue Inhibitors of Matrix Metalloproteinase-3, Potential Therapeutic Target against Multiple Sclerosis. American Journal of Biochemistry and Molecular Biology, 2: 195-199.

DOI: 10.3923/ajbmb.2012.195.199

URL: https://scialert.net/abstract/?doi=ajbmb.2012.195.199

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