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Asian Journal of Biochemistry
  Year: 2020 | Volume: 15 | Issue: 1 | Page No.: 1-6
DOI: 10.3923/ajb.2020.1.6
 
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Insecticidal Oils from the Leaves of Cassia occidentalis and Euphorbia milii May Induce Hormonal Changes in Rats

Okonkwo, Chibuzor Onyinye and Ohaeri, Obioma Christopher

Abstract:
Background and Objectives: The need for natural alternatives to the toxic synthetic chemicals currently used for the control of insect pests and vectors inspired this research. This study analyzed the effect of insecticidal oils obtained from the leaves of Cassia occidentalis and Euphorbia milii on some reproductive hormones in rats. Materials and Methods: Oils were extracted from both plants via soxhlet extraction and administered to rats orally once a week, for 2 weeks. Twenty-eight rats were divided into 7 groups of 4 rats each. The control group (A) received feed and water only, Groups; B1, B2 and B3 received 1500, 3000 and 5000 mg kg1 b.wt., of C. occidentalis oil, while groups C1, C2 and C3 received 1500, 3000 and 5000 mg kg1 b.wt., of E. milii oil. Rats were thereafter sacrificed under light ether anaesthesia. Results: Euphorbia milii oils caused a significant (p<0.05) increase in the concentrations of testosterone, estradiol and luteinizing hormone at 3000 and 5000 mg kg1 b.wt., relative to the control. There was also a significant increase (p<0.05) in luteinizing hormone and testosterone concentrations in rats administered C. occidentalis oil at 3000 and 5000 mg kg1 b.wt., relative to the control. However, no significant (p>0.05) change in estradiol concentration was observed with C. occidentalis oil extract. There was no significant change (p>0.05) in the concentration of most hormones at 1500 mg kg1 b.wt.. Conclusion: Since insecticides are usually applied at much lower concentrations, the plant oils may be considered safe to reproductive hormones in animals.
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How to cite this article:

Okonkwo, Chibuzor Onyinye and Ohaeri, Obioma Christopher, 2020. Insecticidal Oils from the Leaves of Cassia occidentalis and Euphorbia milii May Induce Hormonal Changes in Rats. Asian Journal of Biochemistry, 15: 1-6.

DOI: 10.3923/ajb.2020.1.6

URL: https://scialert.net/abstract/?doi=ajb.2020.1.6

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