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Asian Journal of Biochemistry
  Year: 2017 | Volume: 12 | Issue: 3 | Page No.: 91-98
DOI: 10.3923/ajb.2017.91.98
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Biochemical and Hormonal Effects of Nymphaea lotus Aqueous Extract on Hyperprolactinemic Female Wistar Rats

Olubunmi Josephine Sharaibi and Anthony Jide Afolayan

Background and Objective: Nymphaea lotus (N. lotus) is a medicinal plant used in traditional medicine for the management of hyperprolactinemia and infertility-related diseases. This aim of the study was to investigate the biochemical and hormonal effects of aqueous extract of N. lotus in metoclopramide-induced hyperprolactinemia in rats. Methodology: Hyperprolactinemia was induced by oral administration of 5 mg kg–1 b.wt., metoclopramide to female rats. This was accompanied by administration of graded doses (50, 100 and 200 mg kg–1 b.wt.,) of N. lotus to the rats daily for 21 days, while distilled water and bromocriptine were given to the hyperprolactinemia control and positive control, respectively. Biochemical and hormonal parameters were determined at the end of the experiment using the uterine homogenates and serum, respectively. Results: Significant increase (p<0.05) were observed in the serum prolactin and estradiol level, while follicle stimulating hormone (FSH), luteinizing hormone(LH) and progesterone witnessed reduction, following induction of hyperprolactinemia. Administration of aqueous extract of N. lotus significantly improved (p<0.05) the levels of these hormones especially prolactin and progesterone. It also tends to restore uterine glucose, cholesterol and protein concentration. Conclusion: Aqueous extract of N. lotus especially at dosage of 200 mg kg–1 b.wt., could ameliorate hyperprolactinemia in rats.
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  •    Phytochemical Analysis and in vitro Antioxidant Activity of Nymphaea lotus L.
  •    A Systematic Review on the Efficacy of Herbal Medicines in the Management of Human Drug-induced Hyperprolactinemia; Potential Sources for the Development of Novel Drugs
  •    Effects of Oral Administration of a Decoction on Serum Levels of Leutinizing Hormone, Follicle Stimulating Hormone, Progesterone and Estradiol in Female Dutch-White Rabbits
How to cite this article:

Olubunmi Josephine Sharaibi and Anthony Jide Afolayan, 2017. Biochemical and Hormonal Effects of Nymphaea lotus Aqueous Extract on Hyperprolactinemic Female Wistar Rats. Asian Journal of Biochemistry, 12: 91-98.

DOI: 10.3923/ajb.2017.91.98






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