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Asian Journal of Biochemistry

Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 432-436
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Authors

K. Cheng

C.H. Zou

Keywords

Research Article

Informatics Models of Recognitions of Protein Synthesis

K. Cheng and C.H. Zou
We propose informatics models, using concepts of informative intensity, informative response intensity and informative flux, with different expressions and multiple layers, to describe informative recognitions between a large ribosomal subunit and a complex constructed with a small ribosomal subunit and an initiator tRNA bound on an initiation codon on an mRNA and between base-pairs of a triplet nucleotides (codon) at A site in a ribosome and on an mRNA and a sequence of three complementary nucleotides (anticodon) of a particular tRNA, beyond lengths of chemical bonds, for a natural protein synthesis. In a special expression of (quasi) electrostatics, our model shows the large ribosomal subunit and the complex have a negative informative recognition because they have an attractive force, it is the informative response Intensity to control their relative movements and spatial positions and to make a final decision, for the large ribosomal subunit, to hug, to leave or to ignore the complex. In a special expression of quantum mechanics, our model demonstrates normal complementary base-pairs of the codon and the anticodon have negative Informative Recognitions because their interactive forces are attractive; the other base-pairs have positive informative recognitions because their interactive forces are repulsive. A previous study reported a probability of wrong base-pairs is about 1/10000. With this probability, we estimate a constant barrier height of a potential energy function, the height is about 0.28 eV at a temperature of 37°C.
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