Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Asian Journal of Biochemistry
  Year: 2007 | Volume: 2 | Issue: 4 | Page No.: 208-223
DOI: 10.3923/ajb.2007.208.223
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

An Overview of Biochemical Aspects of DNA Vaccines

Manju Rawat , Deependra Singh , S. Saraf and Swarnlata Saraf

Abstract:
DNA vaccines, also known as genetic or nucleic acid vaccines involve the transfection of cells in vivo by introducing DNA plasmid carrying an antigen-coding gene resulting in an immune response. The purpose of this article is to describe DNA vaccination, to discuss its importance, to review different technologies for improving expression of antigens and to illustrate how it could serve as an alternative for conventional vaccines. DNA vaccines have been prepared against bacterial and viral infections, tumors and allergies and were found to be efficacious in animal studies. These offer number of advantages in terms of ease of administration, manipulation, amplitude and duration of immune response, chemical and biological stabilities and simplicity of manufacture with cost consideration. But, this futuristic alternative needs an elaborate research on its efficacy and associated risks in order to establish the clinical utility of DNA vaccines. This article will explore various aspects of DNA vaccines including its associated advantages, disadvantages, mechanism of action, experimental models studied with a brief overview of second generation vaccines.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    The Epitopes of Foot and Mouth Disease
  •    Advances in Studies on Vaccines of Foot-and-mouth Disease
  •    Natural Immunity to Hemophilus influenza Type b in Children, South of Iran: Need for Vaccination
  •    Construction of a Recombinant Fowlpox Virus Expressing the E0/E2 Proteins of Classical Swine Fever Virus and its Evaluation in Experimental Animals
How to cite this article:

Manju Rawat , Deependra Singh , S. Saraf and Swarnlata Saraf , 2007. An Overview of Biochemical Aspects of DNA Vaccines. Asian Journal of Biochemistry, 2: 208-223.

DOI: 10.3923/ajb.2007.208.223

URL: https://scialert.net/abstract/?doi=ajb.2007.208.223

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

Curve Bottom