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Asian Journal of Animal and Veterinary Advances

Year: 2014 | Volume: 9 | Issue: 9 | Page No.: 556-567
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Authors

Go-Eun Hong

Chang-Won Pyun

Sang-Min Jeong

Kyu-Ho Han

Chi-Ho Lee

Keywords

Research Article

Effects of Fermented Pueraria radix by Lactobacillus acidophilus on Lipid and Bone Metabolism in Ovariectomized Rats

Go-Eun Hong, Chang-Won Pyun, Sang-Min Jeong, Kyu-Ho Han and Chi-Ho Lee
This study was performed to determine the effects of fermented Pueraria radix on lipid and bone metabolism in ovariectomized (OVX) rats. Sprague-Dawley rats were divided into 4 groups: A sham operated control group, an OVX control group, an OVX group, treated Pueraria radix and OVX group treated fermented Pueraria radix. Rats were fed experimental diets with Ca and P free for 8 weeks after ovariectomy. The femur weight was significantly increased in the treatment groups, compared with that of the control group. Abdominal fat mass and serum alanine aminotransferase and aspartate aminotransferase activities and serum triglyceride, total cholesterol, LDL-cholesterol and osteocalcin levels in the treatment groups were significantly decreased compared with the control group. Serum estradiol level in the treatment groups was significantly increased compared with the control group. Bone mineral density of the femur in the fermented Pueraria radix treatment groups was significantly increased than the control group. Further, the result of histopathologic observation was shown in that the treatment of Pueraria radix and fermented Pueraria radix prevented trabecular loss. These results suggest that a P. radix powdered supplement as a source of isoflavones might ameliorate serum cholesterol and estradiol levels and protect against bone loss. Furthermore, fermented P. radix might be more effective than non-fermented P. radix and can be useful as a functional food.
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